Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Ongoing global genome characterization efforts are revolutionizing our knowledge of cancer
genomics and tumor biology. In parallel, information gleaned from these studies on driver …

Cancer cells have diverse biological capabilities that are conferred by numerous genetic
aberrations and epigenetic modifications. Today's powerful technologies are enabling these …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Multiple genetic and epigenetic events characterize tumor progression and define the
identity of the tumors. Advances in high-throughput technologies, like gene expression …

The extent of tumor heterogeneity is an emerging theme that researchers are only beginning
to understand. How genetic and epigenetic heterogeneity affects tumor evolution and …

Cancer comprises a bewildering assortment of diseases that kill 7.5 million people each
year. Poor understanding of cancer's diversity currently thwarts our goal of a cure for every …

Cancer recapitulates Darwinian evolution. Mutations acquired during life that provide cells
with a growth or survival advantage will preferentially multiply to form a tumor. As a result of …