We analyzed the epitope evolution of the spike protein in 1,860,489 SARS-CoV-2 genomes.
The structural dynamics of these epitopes was determined by molecular modeling …

The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …

With the COVID-19 pandemic, the evolutionary fate of SARS-CoV-2 becomes a matter of
utmost concern. Mutation D614G in the spike (S) protein has become dominant, and recent …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel
virus that first occurred in Wuhan in December 2019. The spike glycoproteins and …

Summary The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide, reaching near fixation in a matter of months. Here we show that D614G was …

Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the
previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV …

The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the
viral infection that leads to various levels of COVID-19 severities. Positive evolutionary …

The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
crucial for the infection because it mediates the virus entry into human host-cells, through …

SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …

Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding …