Introduction: Membrane transporters of the SLC and ABC families are abundantly expressed
in the liver, where they control the transfer of drugs/drug metabolites across the sinusoidal …

Cells need to strictly control their internal milieu, a function which is performed by the plasma
membrane. Selective passage of molecules across the plasma membrane is controlled by …

Transporter proteins expressed on the cell membranes of hepatocytes are directly involved
in the hepatic clearance, mediating the transport of drugs and metabolites through the …

Background: Hepatic transporters, including efflux transporters and uptake transporters,
have been recognized to play an important role in the disposition of various drugs. These …

Drug transporters expressed on the hepatocyte membrane play an important role in hepatic
drug disposition. In the last two decades, systematic research has resulted in a better …

In the liver, several approaches are used to investigate and predict the complex issue of
drug-induced transporter inhibition. These approaches include in vitro assays and …

Objectives Membrane transporters and metabolism are major determinants of the
hepatobiliary elimination of drugs. This work investigates several key questions for drug …

Pharmacokinetic analysis involving the measurement of tissue distribution of drugs
contributes to better understanding of the clearance and distribution mechanisms of drugs …

Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

Introduction: The key role of transporter biology in both the manifestation and treatment of
disease is now firmly established. Experiences of sub-optimal drug exposure due to drug …