Identification of potential drug targets for COVID 19 patients with cytokine storm

BC Buana - 2022 - digital.car.chula.ac.th
The outcome of SARS-CoV-2 infection may vary depending on gender, lifestyle, and age.
The elderly is more likely to have the severe condition than the younger population …

Repurposing of drugs for combined treatment of COVID 19 cytokine storm using machine learning

I Tsigelny, M Gantla, V Kouznetsova - 2022 - chemrxiv.org
Context: SARS CoV 2 induced cytokine storm is the major cause of COVID 19 related
deaths. Patients have been treated with drugs that work by inhibiting a specific protein partly …

[HTML][HTML] Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning

MR Gantla, IF Tsigelny, VL Kouznetsova - Medicine in Drug Discovery, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) induced cytokine storm is
the major cause of COVID-19 related deaths. Patients have been treated with drugs that …

Gene expression profiling of corona virus microarray datasets to identify crucial targets in COVID-19 patients

P Ramesh, S Veerappapillai, R Karuppasamy - Gene reports, 2021 - Elsevier
The current outbreak of coronavirus disease (COVID-19) has been affecting millions of
people and has caused devastating mortality worldwide. Moreover, it is to be noted that …

COVID-19: disease pathways and gene expression changes predict methylprednisolone can improve outcome in severe cases

S Draghici, TM Nguyen, LA Sonna, C Ziraldo… - …, 2021 - academic.oup.com
Motivation COVID-19 has several distinct clinical phases: a viral replication phase, an
inflammatory phase and in some patients, a hyper-inflammatory phase. High mortality is …

Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release

M Chan, S Vijay, J McNevin, MJ McElrath… - Molecular systems …, 2021 - embopress.org
Abstract Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced
by massive cytokine production, cellular triggers of this process and strategies to target them …

SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

A Samy, MA Maher, NA Abdelsalam, E Badr - Scientific Reports, 2022 - nature.com
COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus
evolve, a complete comprehension of the disease and drug targets becomes a decisive …

[PDF][PDF] Calming the Storm: Identifying Multi-Cytokine Inhibiting Drugs with Machine Learning for COVID-19 Induced Cytokine Storms

J Hou, VL Kouznetsova, IF Tsigelny - Microbiol Infect Dis, 2022 - scivisionpub.com
In COVID-19, patients in severe condition often suffer from a major complication that leads to
lung injury, ARDS and possibly death: the cytokine storm. The cytokine storm is composed of …

Pharmacotherapeutics for cytokine storm in COVID-19

R Pal, MJ Chaudhary - Stem Cells, 2024 - Elsevier
Cytokine storm (CS) is an acute hyperinflammatory response that may be responsible for
critical illness in many conditions, including viral infections, cancer, sepsis (bacterial), and …

Pathogenesis and treatment of cytokine storm in COVID-19

M Soy, G Keser, MP Atagündüz - Turkish Journal of Biology, 2021 - journals.tubitak.gov.tr
COVID-19 is a viral infection caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) that killed a large number of patients around the world. A hyperinflammatory …