Oxidized low-density lipoprotein retards the growth of proliferating cells by inhibiting nuclear translocation of cell cycle proteins

ME Zettler, MA Prociuk, JA Austria… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—Our study tested the hypothesis that the mitogenic effect of oxidized low-density
lipoprotein (oxLDL) on vascular cells may be further enhanced by the presence of cytokines …

OxLDL stimulates cell proliferation through a general induction of cell cycle proteins

ME Zettler, MA Prociuk, JA Austria… - American Journal …, 2003 - journals.physiology.org
Oxidized low-density lipoprotein (oxLDL) may be involved in atherosclerosis by stimulating
proliferation of cells in the vessel wall. The purpose of this study was to identify the …

Growth-promoting effects of oxidized low density lipoprotein.

ME Zettler, GN Pierce - The Canadian Journal of Cardiology, 2001 - europepmc.org
Oxidized low density lipoprotein (oxLDL) is a causative agent in the development and
progression of atherosclerosis. It is believed to act in part by stimulating the proliferation of …

Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21waf1 and the tumor suppressor Rb

C Mazière, V Marcheux, C Louandre… - … and biophysical research …, 2002 - Elsevier
Oxidized low density lipoprotein (OxLDL) is known to be cytotoxic towards different cell types
of the arterial wall, leading to progression of an atherosclerotic plaque. We previously …

Induction of human endothelial cell growth by mildly oxidized low density lipoprotein

JAM Maier, L Barenghi, S Bradamante, F Pagani - Atherosclerosis, 1996 - Elsevier
The aim of the present study was to examine whether endothelial growth could be
modulated by mildly oxidized low density lipoprotein. When human endothelial cells were …

Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages, and fibroblasts

B Björkerud, S Björkerud - Arteriosclerosis, thrombosis, and …, 1996 - Am Heart Assoc
The inhibition of experimental atherosclerosis by antioxidants and the presence of oxidized
LDL (oxLDL) in atherosclerotic lesions indicate that oxLDL may play what is perhaps a …

Impact of oxidized low density lipoprotein on vascular cells

J Galle, T Hansen-Hagge, C Wanner, S Seibold - Atherosclerosis, 2006 - Elsevier
Oxidized LDL (OxLDL) is a proatherogenic lipoprotein, accumulating in the vascular wall
and contributing to the pathogenesis of vascular dysfunction early in the development of …

Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques

Y Okura, M Brink, H Itabe, KJ Scheidegger… - Circulation, 2000 - Am Heart Assoc
Background—Cytotoxic oxidized LDL (oxLDL) has been shown to promote apoptosis in
cultured vascular smooth muscle cells (VSMCs). We investigated the localization of oxLDL …

Role of oxidized human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation

S Chatterjee - Molecular and cellular biochemistry, 1992 - Springer
The effects of oxidized human plasma low density lipoproteins (Ox-LDL) on the proliferation
of cultured aortic smooth muscle cells was studied, employing viable cell counting,[3 H] …

Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells

A Heinloth, K Heermeier, U Raff… - Journal of the …, 2000 - journals.lww.com
Oxidized low-density lipoprotein (OxLDL) exerts proliferation and apoptosis in vascular cells,
depending on its concentration and the duration of exposure. Recent studies indicate that O …