[HTML][HTML] Colchicine and SARS-CoV-2: management of the hyperinflammatory state

A Vitiello, F Ferrara - Respiratory Medicine, 2021 - Elsevier
The global COVID-19 pandemic is currently underway. In December 2020, the European
Agency of Medicine (EMA) licensed the first Sars-CoV-2 vaccine. Therapeutic management …

[HTML][HTML] Colchicine against SARS-CoV-2 infection: what is the evidence?

AA Drosos, E Pelechas, V Drossou… - Rheumatology and …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a matter of concern worldwide and a huge …

Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia

A Vitiello, F Ferrara, C Pelliccia, G Granata… - Italian Journal of …, 2020 - italjmed.org
For some patients with SARS-CoV-2, the worst clinical damage is not caused by the virus
itself, but by an overactive inflammatory state. In fact, in some people the immune system …

Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study

V Mareev, Y Orlova, A Plisyk, E Pavlikova, Z Akopyan… - 2021 - covid19.neicon.ru
Actuality The course of the novel coronavirus disease (COVID-19) is unpredictable. In some
cases, it manifests as increasing inflammation that leads to a cytokine storm and irreversible …

Anti-inflammatory therapy for COVID-19 infection: the case for colchicine

AZ Reyes, KA Hu, J Teperman… - Annals of the …, 2021 - ard.bmj.com
The search for effective COVID-19 management strategies continues to evolve. Current
understanding of SARS-CoV-2 mechanisms suggests a central role for exaggerated …

Efficacy and safety of colchicine treatment in patients with COVID‐19: a prospective, multicenter, randomized clinical trial

G Pourdowlat, F Saghafi, A Mozafari… - Phytotherapy …, 2022 - Wiley Online Library
Colchicine has shown clinical benefits in the management of COVID‐19 via its anti‐
inflammatory effect. However, the exact role of colchicine in COVID‐19 patients is unknown …

[HTML][HTML] Colchicine in COVID-19: an old drug, new use

N Schlesinger, BL Firestein, L Brunetti - Current pharmacology reports, 2020 - Springer
Abstract Purpose of Review Coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is a pandemic causing havoc …

[HTML][HTML] Colchicine is safe though ineffective in the treatment of severe COVID-19: a randomized clinical trial (COLCHIVID)

A Absalon-Aguilar, M Rull-Gabayet… - Journal of General …, 2022 - Springer
Background Colchicine is an available, safe, and effective anti-inflammatory drug and has
been suggested as a COVID-19 treatment, but its usefulness in hospitalized severe COVID …

Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): a systematic review and meta‐analysis

TI Hariyanto, DA Halim, C Jodhinata… - Clinical and …, 2021 - Wiley Online Library
Currently, there is no widely acceptable and proven effective treatment for coronavirus
disease 2019 (COVID‐19). Colchicine has been shown to offer a benefit in reducing the …

Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial

MIF Lopes, LP Bonjorno, MC Giannini, NB Amaral… - MedRxiv, 2020 - medrxiv.org
Introduction Neutrophilia and high levels of proinflammatory cytokines and other mediators
of inflammation are common finds in patients with severe acute respiratory syndrome due to …