Alzheimer's disease (AD), the most common neurodegenerative disorder associated with
dementia, is typified by the pathological accumulation of amyloid Aβ peptides and …

Cholesterol metabolism is implicated in the etiology of Alzheimer's disease (AD) and
amyloid production in the brain. While brain cholesterol cannot be measured directly in vivo …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized
histopathologically by the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, affecting millions
of people worldwide. Apart from age, the major risk factor identified so far for the sporadic …

High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

The basis for therapeutic strategies targeting the amyloid-β protein (Aβ) has come from
studies showing that accumulation and aggregation of the Aβ within the brain is likely to …

In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are
able to cross the blood–brain barrier. There is a concentration-driven flux of 24S …

Although an immense knowledge has accumulated concerning regulation of cholesterol
homeostasis in the body, this does not include the brain, where details are just emerging …

A leading hypothesis on the pathophysiology of Alzheimer's disease (AD) is the mis-
metabolism of amyloid precursor protein. This mis-metabolism causes the 42-amino acid …

Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary
tangles, and neuronal cell loss associated with membrane cholesterol release. 24S …