Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Aβ)
crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD …

Neurodegeneration, a common feature for many brain disorders, has severe consequences
on the mental and physical health of an individual. Typically human neurodegenerative …

Abnormal cholesterol metabolism is an established feature of Alzheimer's disease (AD).
Cerebrospinal fluid (CSF) is the fluid surrounding the central nervous system, and the …

Converging evidence from clinical and pathological studies indicate the presence of
important relationships between the ongoing deterioration of brain lipid homeostasis …

There is much evidence suggesting that there is a strong relationship between the
deterioration of brain lipid homeostasis, vascular changes and the pathogenesis of …

Background Previous studies have shown that patients with early onset of Alzheimer
disease and vascular dementia have higher levels of circulating brain-derived 24S …

Oxysterols are important for cholesterol homeostasis in the brain and may be affected in
neurodegenerative diseases. The levels of the brain-derived oxysterol 24S …

As neurons die, cholesterol is released in the central nervous system (CNS); hence, this
sterol and its metabolites may represent a biomarker of neurodegeneration, including in …

Oxysterols are a family of 27-carbon cholesterol oxidation derivatives that may be absorbed
with the diet or originated endogenously. These cholesterol metabolites are now considered …

Recently, we demonstrated a net blood-to-brain passage of the oxysterol 27-
hydroxycholesterol corresponding to 4–5 mg/day. As the steady-state levels of this sterol are …