Background: The BRCA1 gene is an important breast-cancer susceptibility gene. Promoter
polymorphisms can alter the binding affinity of transcription factors, changing transcriptional …

Background A study of Chinese women recently suggested that the minor allele of
rs11655505 in the BRCA1 promoter (c.–2265C→ T) increases promoter activity and has a …

It is well established that rare mutations in BRCA2 predispose to familial breast cancer, but
whether common variants at this locus contribute more modest risk to sporadic breast cancer …

Background: AC/T transition—rs4987117 (the Thr1915Met polymorphism) and an A/G
transition—rs11571653 (the Met784Val polymorphism) in the BRCA2 gene were linked to …

Published data on the association between BRCA2 N372H polymorphism and breast
cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta …

Genetic mutation of breast cancer 1 (BRCA1) is one of the most notable factors responsible
for a proportion of breast cancer cases. BRCA1 encodes a 1,863‑amino acid protein and …

Germline mutations in the BRCA1 tumor suppressor gene predispose affected individuals to
breast cancer; however, incomplete cancer penetrance and the presence of phenocopies in …

Most multiple case families of young onset breast cancer and ovarian cancer are thought to
be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2 …

Purpose BRCA1-interacting protein C-terminal helicase 1 (BRIP1) and zinc finger protein
350 (ZNF350) work with BRCA1 in tumor suppression procedures. Low penetrance variants …

Rare, highly penetrant germ line mutations in BRCA1 strongly predispose women to a
familial form of breast and ovarian cancer. Whether common variants (either coding or …