Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade

P Dandona, S Dhindsa, H Ghanim… - Journal of human …, 2007 - nature.com
Abstract Angiotensin II (Ang II) increases adhesion molecules, cytokines and chemokines
and exerts a proinflammatory effect on leucocytes, endothelial cells and vascular smooth …

[PDF][PDF] Angiotensin II and vascular inflammation

ZJ Cheng, H Vapaatalo, E Mervaala - Med Sci Monit, 2005 - researchgate.net
Vascular inflammation is involved in the initiation and progression of atherosclerosis, and is
also present in hypertension-and diabetes-induced vascular complications. Angiotensin II …

Angiotensin II as a pro-inflammatory mediator.

MI Phillips, S Kagiyama - Current opinion in investigational drugs …, 2002 - europepmc.org
Angiotensin II (Ang II), the most important component of the renin-angiotensin system, is
usually associated with hypertension and renal failure. Through its pro-inflammatory actions …

Inflammation may be a bridge connecting hypertension and atherosclerosis

JJ Li, JL Chen - Medical hypotheses, 2005 - Elsevier
Pathogenesis of the atherosclerotic process is deemed as multi-factorial, and characterized
by chronic inflammatory response. Although hypertension is known to be one of the most …

Is angiotensin-II an endogenous pro-inflammatory molecule?

UN Das - Medical Science Monitor: International Medical Journal …, 2005 - europepmc.org
Angiotensin-II, a product of angiotensin converting enzyme (ACE) action, regulates vascular
tone, stimulates the release of pro-inflammatory cytokines, activates NFkappaB, increases …

The renin‐angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies

F Montecucco, A Pende, F Mach - Mediators of inflammation, 2009 - Wiley Online Library
Recent evidence shows that the renin‐angiotensin system is a crucial player in
atherosclerotic processes. The regulation of arterial blood pressure was considered from its …

Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis

VJ Dzau - Hypertension, 2001 - Am Heart Assoc
There is increasing evidence that direct pathobiological events in the vessel wall play an
important role in vascular disease. An important mechanism involves the perturbation of the …

Protective effects of angiotensin II interruption: evidence for antiinflammatory actions

NJ Dagenais, F Jamali - Pharmacotherapy: The Journal of …, 2005 - Wiley Online Library
Angiotensin II, the major effector molecule produced renin‐angiotensin‐aldosterone axis, is
a vasoconstrictor contributing to hypertension. Evidence indicates, however, that …

Proinflammatory effects of angiotensin II and endothelin: targets for progression of cardiovascular and renal diseases

FC Luft - Current Opinion in Nephrology and Hypertension, 2002 - journals.lww.com
Angiotensin II and endothelin-1 can both be regulated by nuclear factor-κB. They are to
varying degrees also capable of activating nuclear factor-κB and increasing the expression …

Inflammation as a regulator of the renin-angiotensin system and blood pressure

R Satou, H Penrose, LG Navar - Current hypertension reports, 2018 - Springer
Abstract Purpose of Review Mechanisms facilitating progression of hypertension via cross
stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed …