Immunomodulatory effects of a cell processing device to ameliorate dysregulated hyperinflammatory disease states

AJ Westover, HD Humes, CJ Pino - Scientific Reports, 2024 - nature.com
Cell directed therapy is an evolving therapeutic approach to treat organ dysfunction arising
from hyperinflammation and cytokine storm by processing immune cells in an extracorporeal …

Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface

K Ganguly, R Luthfikasari, A Randhawa… - Advanced …, 2024 - Wiley Online Library
Macrophages play an essential role in immunotherapy and tissue regeneration owing to
their remarkable plasticity and diverse functions. Recent bioengineering developments have …

Macrophage-associated disorders: pathophysiology, treatment challenges, and possible solutions

K Yadav, M Pradhan, D Singh, MR Singh - Macrophage Targeted Delivery …, 2022 - Springer
Immune disorders are a self-attacking state of our defense mechanism influencing diverse
body tissues and organs. One of the most significant obstacles in treatment for immune …

Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response …

N Kashiwagi, F Saito, H Maegawa, K Kaneda - Cytokine, 2021 - Elsevier
Objective Apoptotic cells participate in maintenance of homeostasis of the adaptive immune
system. Granulocyte/monocyte adsorptive apheresis (GMA) performed with an Adacolumn …

Immunoengineering strategies to enhance vascularization and tissue regeneration

J Zarubova, MM Hasani-Sadrabadi, R Ardehali… - Advanced drug delivery …, 2022 - Elsevier
Immune cells have emerged as powerful regulators of regenerative as well as pathological
processes. The vast majority of regenerative immunoengineering efforts have focused on …

Kinetics of MSC-based enzyme therapy for immunoregulation

A Burr, B Parekkadan - Journal of translational medicine, 2019 - Springer
Background Mesenchymal stromal cells (MSC) demonstrate innate and regulatory
immunologic functions and have been widely explored for cell therapy applications …

[HTML][HTML] Macrophages: the good, the bad, and the gluttony

EA Ross, A Devitt, JR Johnson - Frontiers in immunology, 2021 - frontiersin.org
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

[HTML][HTML] Triggering the resolution of immune mediated inflammatory diseases: can targeting leukocyte migration be the answer?

SJ Hopkin, JW Lewis, F Krautter, M Chimen… - Frontiers in …, 2019 - frontiersin.org
Leukocyte recruitment is a pivotal process in the regulation and resolution of an
inflammatory episode. It is vital for the protective responses to microbial infection and tissue …

Peptide‐based systems analysis of inflammation induced myeloid‐derived suppressor cells reveals diverse signaling pathways

W Choksawangkarn, LM Graham, M Burke… - …, 2016 - Wiley Online Library
A better understanding of molecular signaling between myeloid‐derived suppressor cells
(MDSC), tumor cells, T‐cells, and inflammatory mediators is expected to contribute to more …

[PDF][PDF] Controlled inhibition of the mesenchymal stromal cell pro-inflammatory secretome via microparticle engineering

SH Ranganath, Z Tong, O Levy, K Martyn, JM Karp… - Stem Cell Reports, 2016 - cell.com
Mesenchymal stromal cells (MSCs) are promising therapeutic candidates given their potent
immunomodulatory and anti-inflammatory secretome. However, controlling the MSC …