Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D …

J Querol, M Rodrı́guez-Concepción, A Boronat… - Biochemical and …, 2001 - Elsevier
The first step of the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway for isoprenoid
biosynthesis in plant plastids and most eubacteria is catalyzed by 1-deoxy-d-xylulose 5 …

1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXS), a Crucial Enzyme for Isoprenoids Biosynthesis

S Xiang, G Usunow, G Lange, M Busch… - Isoprenoid synthesis in …, 2013 - Springer
Isopentenyl pyrophosphate (IPP) and its isomer dimethylallyl pyrophosphate (DMAPP) are
the common precursors for the synthesis of all isoprenoids. While IPP and DMAPP are …

Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis

S Xiang, G Usunow, G Lange, M Busch… - Journal of Biological …, 2007 - ASBMB
Isopentenyl pyrophosphate (IPP) is a common precursor for the synthesis of all isoprenoids,
which have important functions in living organisms. IPP is produced by the mevalonate …

Cytidine 5′-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol

F Rohdich, J Wungsintaweekul… - Proceedings of the …, 1999 - National Acad Sciences
2-C-methylerythritol 4-phosphate has been established recently as an intermediate of the
deoxyxylulose phosphate pathway used for biosynthesis of terpenoids in plants and in many …

Exploration of the 1-deoxy-d-xylulose 5-phosphate synthases suitable for the creation of a robust isoprenoid biosynthesis system

K Kudoh, G Kubota, R Fujii, Y Kawano… - Journal of bioscience and …, 2017 - Elsevier
1-Deoxy-d-xylulose 5-phosphate synthase (DXS) is a rate-limiting enzyme in the 2-C-methyl-
d-erythritol 4-phosphate (MEP) pathway, which is responsible for production of two …

Functional and evolutionary analysis of DXL1, a non-essential gene encoding a 1-deoxy-D-xylulose 5-phosphate synthase like protein in Arabidopsis thaliana

L Carretero-Paulet, A Cairó, D Talavera, A Saura… - Gene, 2013 - Elsevier
The synthesis of 1-deoxy-D-xylulose 5-phosphate (DXP), catalyzed by the enzyme DXP
synthase (DXS), represents a key regulatory step of the 2-C-methyl-D-erythritol 4-phosphate …

Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of d-1-deoxyxylulose 5-phosphate, a …

LM Lois, N Campos, SR Putra… - Proceedings of the …, 1998 - National Acad Sciences
For many years it was accepted that isopentenyl diphosphate, the common precursor of all
isoprenoids, was synthesized through the well known acetate/mevalonate pathway …

Hexameric assembly of the bifunctional methylerythritol 2, 4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of …

M Gabrielsen, CS Bond, I Hallyburton, S Hecht… - Journal of Biological …, 2004 - ASBMB
The bifunctional methylerythritol 4-phosphate cytidylyltransferase methylerythritol 2, 4-
cyclodiphosphate synthase (IspDF) is unusual in that it catalyzes nonconsecutive reactions …

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-d-xylulose 5-phosphate precursor to isoprenoids, thiamin …

GA Sprenger, U Schörken, T Wiegert… - Proceedings of the …, 1997 - National Acad Sciences
In Escherichia coli, 1-deoxy-d-xylulose (or its 5-phosphate, DXP) is the biosynthetic
precursor to isopentenyl diphosphate [Broers, STJ (1994) Dissertation (Eidgenössische …

Catalytically important residues in E. coli 1-deoxy-d-xylulose 5-phosphate synthase

J Querol-Audí, A Boronat, JJ Centelles, S Imperial - 2014 - digital.csic.es
1-deoxy-D-xylulose 5-phosphate synthase (DXS) catalyzes the initial step of the 2-C-methyl-
D-erythritol 4-phosphate (MEP) pathway consisting in the condensation of (hydroxiethyl) …