RNA interfering (RNAi), mediated by small interfering RNAs and microRNAs, is currently one
of the most promising tools of gene therapy. Small RNAs are capable of inducing specific …

Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug
delivery vectors due to their biological origin, abundance, and intrinsic capability in …

Harnessing exosomes as therapeutic drug delivery vehicles requires a better understanding
of exosomal composition and their mode of action. A full appreciation of all the exosomal …

Exosomes are nanovesicles released from cells due to pathophysiological events. These
nanoparticles are resistant to metabolic destruction and can transcend the blood-brain …

The effective delivery of target-specific siRNA to the brain by exploiting the exosomes
derived from dendritic cells renders the paradigm shift for the prospective use of nanosized …

All forms of life produce nanosized extracellular vesicles called exosomes, which are
enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and …

Recently, various innovative therapies involving the ex vivo manipulation and subsequent
reintroduction of exosome‐based therapeutics into humans have been developed and …

With recent advances in nanotechnology and therapeutic nucleic acids (TNAs), various
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …

The demonstration that dendritic cell (DC)‐derived exosomes can be exploited for targeted
RNAi delivery to the brain after systemic injection provides the first proof‐of‐concept for the …

Exosomes are extracellular vesicles released from cells and are characterized by a lipid
bilayer membrane encapsulating a variety of biological molecules such as nucleic acids or …