Evolutionary theories of aging predict the existence of certain genes that provide selective
advantage early in life with adverse effect on lifespan later in life (antagonistic pleiotropy …

Complex diseases are major contributors to human mortality in old age. Paradoxically, many
genetic variants that have been associated with increased risks of such diseases are found …

This short review portrays the evolutionary theories of aging in the light of the existing
discoveries from genomic and molecular genetic studies on aging and longevity. At the …

There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

While the questions of “What causes aging?” and “Why do we age?” and “How can we stop
it?” remain unanswered, recent advances in aging research have continued to increase our …

Over the last 30 years, a number of genetic and environmental factors that lead to decreased
length of life have been identified. Unfortunately, much less progress has been achieved in …

Once thought to be an extremely complex conundrum of weak genetic and environmental
effects, exceptional longevity is beginning to yield genetic findings. Numerous lower …

Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

In humans, aging is inexorable. The progressive decrease in physiological capacity and the
reduced ability to respond to environmental stresses lead to increased susceptibility and …

Senescence violates the most basic tenet of natural selection by causing death rather than
individual survival. Thus, current theories favor the concept of antagonistic pleiotropy (AP) to …