Senescence induces key phenotypic changes that can modulate immune responses. Four
recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how …

Cellular senescence is a stress response that activates innate immune cells, but little is
known about its interplay with the adaptive immune system. Here, we show that senescent …

Senescent cells as thermostats of antitumor immunity | Science Translational Medicine news
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When the tumour is at bay, the CD8+ T cells come out to play | Nature Reviews Cancer Skip to
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The functional state of the preexisting T cells in the tumor microenvironment is a key
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …

In response to a variety of cancer-inducing stresses, cells may engage a stable cell cycle
arrest mechanism, termed cellular senescence, to suppress the proliferation of preneoplastic …

Immunotherapies have revolutionized cancer treatment, but despite the many lives that have
been extended by these therapies many patients do not respond for reasons that are not …

Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that,
in some instances, stimulates the immune clearance of senescent cells. Using an immune …

The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …

Cellular senescence is a stress response that activates innate immunity. However, the
interplay between senescent cells and the adaptive immune system remains largely …