A new paradigm for the pathobiology of periodontitis is presented, and the manner in which
periodontitis may relate to susceptibility for certain systemic diseases such as cardiovascular …

Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the
sixth most common human disease and is estimated to affect 11.2% of the global adult …

Much work has been published on the association between periodontal disease and
systemic disease, including original reports, narrative reviews, systematic reviews, and meta …

Extraordinary progress is being made in understanding the relationship between
periodontal disease and systemic health. Periodontitis, one of the oldest and most common …

Systemic conditions and disorders are now considered to be secondary factors modulating
disease initiation or progression rather than acting as primary etiological factors. The current …

The pathogenesis of human periodontitis was placed on a rational footing for the first time by
Page & Schroeder in 1976 (7). Although the details were scanty, the general principles and …

There has been a resurgence of interest in recent years in the systemic effects of oral
infections such as periodontal diseases. The study of the various means by which …

This article provides a brief review of findings from epidemiological studies of periodontal
disease that have been generated over the past five years. In line with the conclusions of the …

The possibility that a localized oral condition such as periodontal disease (PD) may have
systemic effects seems to be of interest to the average person. The notion that a condition …

The purpose of this volume of PERIODONTOLOGY 2000 is to present the basic concepts
and facts constituting the current understanding of the pathogenesis of human periodontitis …