Generic and context-dependent gene modulations during Hydra whole body regeneration

Y Wenger, W Buzgariu, C Perruchoud, G Loichot… - BioRxiv, 2019 - biorxiv.org
The cnidarian Hydra is a classical model of whole-body regeneration. Historically, Hydra
apical regeneration has received more attention than its basal counterpart, most studies …

Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

JF Cazet, A Cho, CE Juliano - Elife, 2021 - elifesciences.org
During whole-body regeneration, a bisection injury can trigger two different types of
regeneration. To understand the transcriptional regulation underlying this adaptive …

A comprehensive transcriptomic and proteomic analysis of hydra head regeneration

HO Petersen, SK Höger, M Looso… - Molecular biology …, 2015 - academic.oup.com
The cnidarian freshwater polyp Hydra sp. exhibits an unparalleled regeneration capacity in
the animal kingdom. Using an integrative transcriptomic and stable isotope labeling by …

From injury to patterning—MAPKs and Wnt signaling in Hydra

A Tursch, TW Holstein - Current Topics in Developmental Biology, 2023 - Elsevier
Hydra has a regenerative capacity that is not limited to individual organs but encompasses
the entire body. Various global and integrative genome, transcriptome and proteome …

Cellular and Molecular Mechanisms of Hydra Regeneration

PC Reddy, A Gungi, M Unni - Evo-Devo: Non-model Species in Cell and …, 2019 - Springer
Regeneration of lost body parts is essential to regain the fitness of the organism for
successful living. In the animal kingdom, organisms from different clades exhibit varied …

Spatio-temporal Coordination of Active Deformation Forces and Wnt / Hippo-Yap Signaling in Hydra Regeneration

R Suzuki, T Hiraiwa, A Tursch, S Höger, K Hayashi… - BioRXiv, 2023 - biorxiv.org
Ample evidence suggests that Wnt signaling and tissue deformation are key determinants
for pattern formation in animals. The coordination of these biochemical and biomechanical …

Injury-induced MAPK activation triggers body axis formation in Hydra by default Wnt signaling

A Tursch, N Bartsch, M Mercker… - Proceedings of the …, 2022 - National Acad Sciences
Hydra's almost unlimited regenerative potential is based on Wnt signaling, but so far it is
unknown how the injury stimulus is transmitted to discrete patterning fates in head and foot …

[HTML][HTML] β-Catenin acts in a position-independent regeneration response in the simple eumetazoan Hydra

S Gufler, B Artes, H Bielen, I Krainer, MK Eder… - Developmental …, 2018 - Elsevier
Wnt/β-Catenin signaling plays crucial roles in regenerative processes in eumetazoans. It
also acts in regeneration and axial patterning in the simple freshwater polyp Hydra, whose …

Hydra, a niche for cell and developmental plasticity

B Galliot, M Miljkovic-Licina, R de Rosa… - Seminars in cell & …, 2006 - Elsevier
The silencing of genes whose expression is restricted to specific cell types and/or specific
regeneration stages opens avenues to decipher the molecular control of the cellular …

Injury‐induced activation of the MAPK/CREB pathway triggers apoptosis‐induced compensatory proliferation in hydra head regeneration

S Chera, L Ghila, Y Wenger… - Development, growth & …, 2011 - Wiley Online Library
After bisection, Hydra polyps regenerate their head from the lower half thanks to a head‐
organizer activity that is rapidly established at the tip. Head regeneration is also highly …