Pharmacological interventions for COVID-19: a systematic review of observational studies and clinical trials

N Bokharee, YH Khan, A Khokhar… - Expert Review of Anti …, 2021 - Taylor & Francis
Introduction: Currently, there is no approved therapeutic entity for coronavirus disease 2019
(COVID-19) and clinicians are primarily relying on drug repurposing. However, findings …

Old and re-purposed drugs for the treatment of COVID-19

SS Jean, PR Hsueh - Expert review of anti-infective therapy, 2020 - Taylor & Francis
Introduction: The coronavirus disease 2019 (COVID-19) caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed since December 2019. It …

Therapeutic management of COVID-19 patients: Clinical manifestation and limitations

U Fatima, SSA Rizvi, N Raina, S Fatima… - Current …, 2021 - ingentaconnect.com
Coronavirus disease-2019 (COVID-19) is a respiratory tract infection accompanied by
severe or fatal pneumonia-like symptoms and sometimes death. It has posed to be an …

Tocilizumab and COVID-19: timing of administration and efficacy

E Abidi, WS El Nekidy, E Alefishat, N Rahman… - Frontiers in …, 2022 - frontiersin.org
Elevated concentrations of interleukin-6 have been demonstrated to be an important key
factor in COVID-19 host immune impairment. It represents an important prognostic factor of …

Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19

L Abbasian, N Toroghi, H Rahmani, H Khalili… - International …, 2022 - Elsevier
Objectives This study was designed to compare the efficacy and safety of
methylprednisolone and tocilizumab in the treatment of patients with severe COVID-19 …

Is there any potential management against COVID-19? A systematic review and meta-analysis

H Talaie, SM Hosseini, M Nazari, Y Fakhri… - DARU Journal of …, 2020 - Springer
Purpose A recent survey has shown that the COVID-19 pandemic has culminated in
dramatical and critical treatment particularly in acute infected patients. In fact, this systematic …

Systematic review on treatment trials of tocilizumab: a repurposing drug against COVID-19

S Banerjee, AK Mahapatra - Reviews on Recent Clinical Trials, 2021 - ingentaconnect.com
Background: Coronavirus disease (COVID-19) caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) has become a global issue today. There exists an …

Tocilizumab in COVID-19 management: addressing time of starting treatment

S Khiali, T Entezari-Maleki - European Journal of Hospital Pharmacy, 2023 - ejhp.bmj.com
Identifying effective and safe therapies for the management of patients with coronavirus
disease 2019 (COVID-19) is crucial in the control of the pandemic. The critical role of …

Comparing the efficacy of tocilizumab with corticosteroid therapy in treating COVID-19 patients: A systematic review and meta-analysis

PC Lim, KL Wong, R Rajah, MF Chong… - DARU Journal of …, 2022 - Springer
Purpose Tocilizumab has shown equivocal outcomes in reducing mortality in COVID-19.
The corticosteroids appear to be an affordable alternative to tocilizumab. This study aims to …

Efficacy of COVID-19 treatments: a Bayesian network meta-analysis of randomized controlled trials

C Zhang, H Jin, YF Wen, G Yin - Frontiers in Public Health, 2021 - frontiersin.org
Background: We provided a comprehensive evaluation of efficacy of available treatments for
coronavirus disease 2019 (COVID-19). Methods: We searched for candidate COVID-19 …