Objective: Mental disorders are heritable and polygenic, and genome-wide genetic
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …

Genome-wide association studies (GWAS) have been performed for many psychiatric
disorders and revealed a complex polygenic architecture linking mental and physical health …

Over the last two years genome-wide association studies (GWAS) have made major
contributions to understanding the genetic architecture of many common human diseases …

Understanding which biological pathways are specific versus general across diagnostic
categories and levels of symptom severity is critical to improving nosology and treatment of …

Hundreds of genome-wide association studies have been performed in recent years in order
to try to identify common variants that associate with complex disease. These have met with …

Genetic discoveries about human brain development and neuropsychiatric syndromes have
changed the landscape of psychiatric research. The genotyping of hundreds of thousands of …

Decades of research in the pre-molecular genetics era firmly established that major
psychiatric disorders are highly to moderately heritable, but only with the emergence of …

Background Despite evidence from twin and family studies for an important contribution of
genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly …

As it is likely that both common and rare genetic variation are important for complex disease
risk, studies that examine the full range of the allelic frequency distribution should be utilized …

Editorial summary Endophenotypes, quantitative neurobehavioral traits that index genetic
susceptibility for a psychiatric disorder, have been examined in thousands of studies …