The human genome project has spurred great enthusiasm in many research communities
and, of special interest to readers of Biological Psychiatry, has raised hope that genetic …

Recent large-scale genetic approaches such as genome-wide association studies have
allowed the identification of common genetic variations that contribute to risk architectures of …

Abstract The Genomic Psychiatry Cohort (GPC) is a longitudinal resource designed to
provide the necessary population‐based sample for large‐scale genomic studies, studies …

Genome-wide association studies and other discovery genetics methods provide a means to
identify previously unknown biological mechanisms underlying behavioral disorders that …

Over the last years, the decreased costs and enhanced accessibility to large genome-wide
association studies datasets have laid the foundations for the development of polygenic risk …

Objectives. Psychiatric disorders are among the most heritable common disorders, and for
more than 20 years researchers have tried to unravel genetic susceptibility genes. This …

Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …

Several psychiatric disorders—such as bipolar disorder, schizophrenia and autism—are
highly heritable, yet identifying their genetic basis has been challenging, with most …

Genome-wide association studies (GWAS) and family-based studies have revealed partly
overlapping genetic architectures between various psychiatric disorders. Given clinical …

Objective: The authors conducted a review of the history and empirical basis of genomewide
association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date …