The hypothesis that multiple genetic variants contribute to psychiatric disorders was first
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …

The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet
recent studies, especially in the past year, have confirmed genetics as the major cause of …

Neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit
hyperactivity disorder (ADHD), schizophrenia (SCZ), bipolar disorder (BIP), and major …

Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of
causal genetic variants that span much of the genome. This widespread polygenicity …

Genetic factors play a fundamental role in the genesis of many mental disorders. The
identification of the underlying genetic variation will therefore transform parts of psychiatry …

Abstract Purpose of Review The following review provides some description of the
movement in cross-disorder psychiatric genomics toward addressing both comorbidity and …

Supported by technological advances and collaborative efforts, psychiatric genetics has
provided robust genetic findings in the past decade, particularly through genome-wide …

Recent genomic studies have revealed the highly polygenic nature of psychiatric disorders,
including schizophrenia, bipolar disorder and major depressive disorder. Many of the …

BackgroundMounting evidence shows genetic overlap between multiple psychiatric
disorders. However, the biological underpinnings of shared risk for psychiatric disorders are …

Over the last 8 years the Psychiatric Genomics Consortium (PGC; http://pgc. unc. edu) has
fundamentally changed the landscape for psychiatric genetics research. This has been …