Study on structure activity relationship of natural flavonoids against thrombin by molecular docking virtual screening combined with activity evaluation in vitro

X Wang, Z Yang, F Su, J Li, EO Boadi, Y Chang… - Molecules, 2020 - mdpi.com
Thrombin, a key enzyme of the serine protease superfamily, plays an integral role in the
blood coagulation cascade and thrombotic diseases. In view of this, it is worthwhile to …

A series of natural flavonoids as thrombin inhibitors: Structure-activity relationships

L Liu, H Ma, N Yang, Y Tang, J Guo, W Tao - Thrombosis Research, 2010 - Elsevier
A series of natural flavonoids has been evaluated as potential inhibitors of thrombin using
the optimized method of thrombin time. Myricetin and quercetin have shown to be the best …

Investigation of interactions between thrombin and ten phenolic compounds by affinity capillary electrophoresis and molecular docking

QQ Li, YX Yang, JW Qv, G Hu, YJ Hu… - Journal of Analytical …, 2018 - Wiley Online Library
Thrombin plays a vital role in blood coagulation, which is a key process involved in
thrombosis by promoting platelet aggregation and converting fibrinogen to form the fibrin …

Thrombin inhibitory activity of some polyphenolic compounds

M Bijak, R Ziewiecki, J Saluk, M Ponczek… - Medicinal Chemistry …, 2014 - Springer
Thrombin, also known as an active plasma coagulation factor II, belongs to the family of
serine proteases and plays a crucial role in blood coagulation process. The process of …

Marine diterpenes: Molecular modeling of thrombin inhibitors with potential biotechnological application as an antithrombotic

RCC Pereira, AL Lourenço, L Terra, PA Abreu… - Marine Drugs, 2017 - mdpi.com
Thrombosis related diseases are among the main causes of death and incapacity in the
world. Despite the existence of antithrombotic agents available for therapy, they still present …

Identification of the functional food ingredients with antithrombotic properties via virtual screen and experimental studies

X Zheng, P Pu, B Ding, W Bo, D Qin, G Liang - Food Chemistry, 2021 - Elsevier
Thrombin is a key therapeutic target protein of thrombosis. To date, massive studies have
focused on the exploration of antithrombotic compounds. Here we capitalize on molecular …

[HTML][HTML] Functional and binding studies of gallic acid showing platelet aggregation inhibitory effect as a thrombin inhibitor

Y Zhang, X Wang, B Lu, Y Gao, Y Zhang, Y Li… - Chinese Herbal …, 2022 - Elsevier
Objective This study was devoted to identifying natural thrombin inhibitors from traditional
Chinese medicine (TCM) and evaluating its biological activity in vitro and binding …

[HTML][HTML] Thrombolytic activity, drug likeness property and ADME/T analysis of isolated phytochemicals from ginger (Zingiber officinale) using in silico approaches

S Hossain, B Sarkar, MNI Prottoy, Y Araf… - Modern Research in …, 2019 - scirp.org
This experiment has been carried out to observe the potential thrombolytic activity of
naturally occuring phytochemicals in Ginger (Zingiber officinale) and to analyze their drug …

Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin

LH Wei, TR Chen, HB Fang, Q Jin, SJ Zhang… - International journal of …, 2019 - Elsevier
Thrombin, a multifunctional serine protease responsible for the proteolytic hydrolysis of
soluble fibrinogen, plays a pivotal role in the blood coagulation cascade. Currently, thrombin …

Biflavones from Ginkgo biloba as inhibitors of human thrombin

TR Chen, LH Wei, XQ Guan, C Huang, ZY Liu… - Bioorganic …, 2019 - Elsevier
Ginkgo Biloba leaf extract has been widely used for the prevention and treatment of
thrombosis and cardiovascular disease in both eastern and western countries, but the …