The nasal epithelium is an important target for drug delivery to the nose and secondary
organs such as the brain via the olfactory bulb. For both topical and brain delivery, the …

Abstract Central Nervous System (CNS) disorders are one of the major causes of fatalities in
the world today. Thus, it is essential to transport a considerable amount of drugs to a specific …

Purpose Nose-to-brain drug administration along the olfactory and trigeminal nerve
pathways offers an alternative route for the treatment of central nervous system (CNS) …

Background: Targeting drugs to the olfactory region in the nasal cavity can bypass the
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …

Direct nose-to-brain drug delivery, a promising approach for treating neurological disorders,
faces challenges due to anatomical variations between adults and children. This study aims …

A human nasal cavity was reconstructed from CT scans to make a Computational Fluid
Dynamics (CFD) model. With this model, fluid flow and inhalation of aerosol analysis can be …

Purpose Aerosol particle deposition in the human nasal cavity is of high interest in particular
for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The …

The complex nasal structure poses obstacles for efficient nasal drug administration beyond
the nasal valve, especially when targeting the olfactory region. This study numerically …

The present work examines regional deposition within the nose for nasal sprays over a large
and wide ranging parameter space by using numerical simulation. A set of 7 realistic adult …

The nasal olfactory region is a potential route for non-invasive delivery of drugs directly from
the nasal epithelium to the brain, bypassing the often impermeable blood-brain barrier …