Dilute suspension flow with nanoparticle deposition in a representative nasal airway model

H Shi, C Kleinstreuer, Z Zhang - Physics of Fluids, 2008 - pubs.aip.org
The human nasal cavities with an effective length of only 10 cm feature a wide array of basic
flow phenomena because of their complex geometrics. Employing a realistic nasal airway …

Numerical simulation of airflow, particle deposition and drug delivery in a representative human nasal airway model

H Shi - 2007 - repository.lib.ncsu.edu
The human nasal cavities, each with an effective length of only 10cm, feature a wide array of
basic flow phenomena due to their complex geometries. Dependent on such airflow fields …

Numerical simulation investigation of drug deposition process during nasal administration with auxiliary airflow

HX Ren, LX Zhang, G Guo, ZB Tong, ZY Li, Y Zhang… - Powder Technology, 2023 - Elsevier
Successful delivery of drugs to the Olfactory region (OR) is the key to treating diseases
through the nasal cavity. The purpose of this paper is to investigate the effect of auxiliary …

Airflow and nanoparticle deposition in rat nose under various breathing and sniffing conditions—A computational evaluation of the unsteady and turbulent effect

J Jiang, K Zhao - Journal of aerosol science, 2010 - Elsevier
Accurate prediction of nanoparticle (1–100nm) deposition in the rat nasal cavity is important
for assessing the toxicological impact of inhaled nanoparticles as well as for potential …

Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model

JD Schroeter, JS Kimbell… - Journal of Aerosol …, 2006 - liebertpub.com
The human nasal passages effectively filter particles from inhaled air. This prevents harmful
pollutants from reaching susceptible pulmonary airways, but may leave the nasal mucosa …

Comparison of micron-and nano-particle transport in the human nasal cavity with a focus on the olfactory region

S Vachhani, C Kleinstreuer - Computers in Biology and Medicine, 2021 - Elsevier
Intranasal administration of drugs serves as a promising, noninvasive option for the
treatment of various disorders of the central nervous system and upper respiratory tract …

In vitro evaluation of nasal aerosol depositions: an insight for direct nose to brain drug delivery

A Maaz, IS Blagbrough, PA De Bank - Pharmaceutics, 2021 - mdpi.com
The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

Machine learning and sensitivity analysis for predicting nasal drug delivery for targeted deposition

H Calmet, D Dosimont, D Oks, G Houzeaux… - International Journal of …, 2023 - Elsevier
Targeted nasal drug delivery can provide improved efficacy for drug formulations to be
delivered at high efficacy rates. Some parameters that influence drug delivery have a …

Parameter characteristics in intranasal drug delivery: A key to targeting medications to the olfactory airspace

RM Sicard, DO Frank-Ito - Clinical Biomechanics, 2024 - Elsevier
Background The nose is a viable pathway for topical drug delivery to the olfactory cleft for
treatment of obstructive smell loss and nose-to-brain drug delivery. This study investigates …

Numerical analysis of nanoparticle transport and deposition in a cynomolgus monkey nasal passage

J Dong, J Ma, L Tian, K Inthavong… - International Journal for …, 2021 - Wiley Online Library
Environmental exposure to toxic agents is commonly encountered by occupational and
residential populations. However, in vivo exposure data in human subjects is limited by …