In vivo experiments have shown that nanoparticles depositing in the rat olfactory region can
translocate to the brain via the olfactory nerve. Quantitative predictions of the dose delivered …

Micron-sized particle deposition in anatomically realistic models of a rat and human nasal
cavity was numerically investigated. A steady laminar inhalation flow rate was applied and …

The nasal cavity is the inlet to the human respiratory system and is responsible for the
olfactory sensation, filtering pollutant particulate matter, and humidifying the air. Many …

Identifying the deposition pattern of inhaled pharmaceutical aerosols in the human
respiratory system and understanding the effective parameters in this process is vital for …

Purpose: The objective of this study was to develop a computational fluid dynamics (CFD)
model to predict the deposition, dissolution, clearance, and absorption of pharmaceutical …

Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …

To understand inhaled nanoparticle transport and deposition characteristics in pediatric
nasal airways with adenoid hypertrophy (AH), with a specific emphasis on the olfactory …

The deposition of ultrafine aerosols in the respiratory tract presents a significant health risk
due to the increased cellular-level response that these particles may invoke. However, the …

Evaluation of nasal spray drug absorption has been challenging because deposited
particles are consistently transported away by mucociliary clearance during diffusing …

Accurate and realistic predictions of the fate of nasally inhaled generic drugs provide new
physical insight which can be of great importance to toxicologists, drug developers and …