Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions
Deposition of polydisperse particles representing nasal spray application in a human nasal
cavity was performed under transient breathing profiles of sniffing, constant flow, and breath …
cavity was performed under transient breathing profiles of sniffing, constant flow, and breath …
Effects of subject-variability on nasally inhaled drug deposition, uptake, and clearance
S Chari, K Sridhar, C Kleinstreuer - Journal of Aerosol Science, 2022 - Elsevier
Accurate and realistic predictions of the fate of nasally inhaled generic drugs provide new
physical insight which can be of great importance to toxicologists, drug developers and …
physical insight which can be of great importance to toxicologists, drug developers and …
Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles
J Xi, PW Longest - 2008 - asmedigitalcollection.asme.org
The deposition of ultrafine aerosols in the respiratory tract presents a significant health risk
due to the increased cellular-level response that these particles may invoke. However, the …
due to the increased cellular-level response that these particles may invoke. However, the …
Comparison of micron-and nanoparticle deposition patterns in a realistic human nasal cavity
SM Wang, K Inthavong, J Wen, JY Tu… - Respiratory physiology & …, 2009 - Elsevier
Knowledge regarding particle deposition processes in the nasal cavity is important in
aerosol therapy and inhalation toxicology applications. This paper presents a comparative …
aerosol therapy and inhalation toxicology applications. This paper presents a comparative …
Protein aerosol for intranasal nose to brain (N2B) delivery
M Stützle, S Carle, L Engelhardt, U Simon… - BMC Proceedings, 2015 - Springer
Background For the treatment of metabolic and neurodegenerative diseases, drug delivery
to the central nervous system (CNS) has gained considerable recent interest [1, 2]. But many …
to the central nervous system (CNS) has gained considerable recent interest [1, 2]. But many …
Validation of anatomical models to study aerosol deposition in human nasal cavities
S Le Guellec, D Le Pennec, S Gatier, L Leclerc… - Pharmaceutical …, 2014 - Springer
Purpose Intranasal deposition of aerosols is often studied using in vitro nasal cavity models.
However, the relevance of these models to predict in vivo human deposition has not been …
However, the relevance of these models to predict in vivo human deposition has not been …
Design and testing of electric-guided delivery of charged particles to the olfactory region: Experimental and numerical studies
J Xi, J Eddie Yuan, M Alshaiba, D Cheng… - Current Drug …, 2016 - ingentaconnect.com
Neurological drugs delivered to the olfactory region can enter the brain via olfactory
pathways and bypass the blood-brain barrier. However, clinical applications of the direct …
pathways and bypass the blood-brain barrier. However, clinical applications of the direct …
Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness
H Shi, C Kleinstreuer, Z Zhang - Journal of Aerosol Science, 2007 - Elsevier
Nasal inhalation helps to protect the lungs from detrimental effects of toxic particles which,
however, may also place the nasal and adjacent tissues at risk. Alternatively, drug–aerosol …
however, may also place the nasal and adjacent tissues at risk. Alternatively, drug–aerosol …
Targeted drug delivery to the inferior meatus cavity of the nasal airway using a nasal spray device with angled tip
Abstract Background and Objective: Nowadays, by advancement in computational tools,
Computational Fluid and Particle Dynamics (CFPD) technique can be used more than ever …
Computational Fluid and Particle Dynamics (CFPD) technique can be used more than ever …