Background One of the most promising approaches to understand inhalation toxicology and
to assess the potential risks of inhaled particles is to examine the disposition of the …

Nasal sprays are typically characterized using in vitro spray metrics such as spray cone
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …

The nasal cavity has been used as a route of drug administration for many decades for
topical therapies and more recently for systemic delivery. Several factors should be taken …

Nanocarrier-aided drug delivery techniques have improved the absorption and permeability
of drugs in nose-to-brain delivery. However, the molecular properties of nanocarriers during …

Until quite recently nasal delivery of pharmaceutical formulations was confined largely to
locally acting therapeutics such as decongestants and antihistamines. Today though, the …

Many studies suggest limited effectiveness of spray devices for nasal drug delivery due
primarily to high deposition and clearance at the front of the nose. Here, nasal spray …

The development of nose-to-brain drug delivery and therapies for olfactory dysfunctions has
been hurdled by the challenges to delivering clinically significant doses to the olfactory …

The intricate anatomical and physiological barriers that prohibit pharmaceuticals from
entering the brain continue to provide a noteworthy hurdle to the efficient distribution of …

The objective of this study was to link regional nasal spray deposition patterns of suspension
formulations, predicted with computational fluid dynamics, to in vivo human pharmacokinetic …

Background: The aim of this work is to use an experimental design approach to identify and
study influential formulation and delivery device properties, which can be controlled by final …