T Wu, J Dong, J Fu, Y Kuang, B Chen, H Gu, Y Luo… - Science, 2022 - science.org
Meiotic spindle assembly ensures proper chromosome segregation in oocytes. However, the mechanisms behind spindle assembly in human oocytes remain largely unknown. We …
INTRODUCTION When an egg is fertilized by a sperm, the chromosomes of the mother and the father become united, and a genetically unique embryo starts to form. A healthy embryo …
C So, KB Seres, AM Steyer, E Mönnich, D Clift… - Science, 2019 - science.org
INTRODUCTION Mammalian embryos frequently develop abnormally, resulting in miscarriages and genetic disorders such as Down syndrome. The major cause for aberrant …
Z Holubcová, M Blayney, K Elder, M Schuh - Science, 2015 - science.org
Aneuploidy in human eggs is the leading cause of pregnancy loss and several genetic disorders such as Down syndrome. Most aneuploidy results from chromosome segregation …
C Thomas, T Cavazza, M Schuh - Biochemical Society …, 2021 - portlandpress.com
Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects∼ 10–25% of eggs in women in their early 30s, and more …
J Roeles, G Tsiavaliaris - Nature communications, 2019 - nature.com
Mammalian oocytes assemble a bipolar acentriolar microtubule spindle to segregate chromosomes during asymmetric division. There is increasing evidence that actin in the …
Chromosome segregation in mammalian oocytes is driven by a microtubule spindle lacking centrosomes. Here, we analyze centrosome-independent spindle assembly by quantitative …
M Schuh, J Ellenberg - Current Biology, 2008 - cell.com
An oocyte matures into an egg by extruding half of the chromosomes in a small polar body. This extremely asymmetric division enables the oocyte to retain sufficient storage material …
B Mogessie, K Scheffler, M Schuh - Annual review of cell and …, 2018 - annualreviews.org
Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual cycle, an oocyte matures into a fertilizable egg in the ovary. To this end, the oocyte …