[PDF][PDF] Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19

L Valdenassi, M Franzini, G Ricevuti… - Eur Rev Med …, 2020 - orbisphera.org
In fact, reacting with target substrates in biological fluids (PUFA and GSH), leads to the
creation of hydroperoxides and aldehydes. Among them, 4-HNE (4 hydroxyl-nonenal) is a …

Insights on the mechanisms of action of ozone in the medical therapy against COVID-19

S Chirumbolo, L Valdenassi, V Simonetti… - International …, 2021 - Elsevier
An increasing amount of reports in the literature is showing that medical ozone (O 3) is used,
with encouraging results, in treating COVID-19 patients, optimizing pain and symptoms …

The Mito-Hormetic mechanisms of ozone in the clearance of SARS-CoV2 and in the COVID-19 therapy

S Chirumbolo, A Varesi, M Franzini, L Valdenassi… - Biomedicines, 2022 - mdpi.com
An increasing body of evidence in the literature is reporting the feasibility of using medical
ozone as a possible alternative and adjuvant treatment for COVID-19 patients, significantly …

Ozone (O3) and SARS-CoV-2: physiological bases and their therapeutic possibilities according to COVID-19 evolutionary stage

ME Fernández-Cuadros, MJ Albaladejo-Florín… - SN Comprehensive …, 2020 - Springer
To date, there is no definitive treatment for the new SARS-CoV-2 pandemic. Three
evolutionary stages in SARS-CoV-2 infection are recognized (early infection, pulmonary …

Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19

G Martínez-Sánchez, A Schwartz, V Di Donna - Antioxidants, 2020 - mdpi.com
(1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak …

Preliminary findings on the association of the lipid peroxidation product 4-hydroxynonenal with the lethal outcome of aggressive COVID-19

N Žarković, B Orehovec, L Milković, B Baršić, F Tatzber… - Antioxidants, 2021 - mdpi.com
Major findings of the pilot study involving 21 critically ill patients during the week after
admission to the critical care unit specialized for COVID-19 are presented. Fourteen patients …

Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease

B Yousefi, SZ Banihashemian, ZK Feyzabadi… - Medical Gas …, 2022 - journals.lww.com
Atmospheric ozone is produced when nitrogen oxides react with volatile organic
compounds. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome …

COVID-19 and heme oxygenase: novel insight into the disease and potential therapies

PL Hooper - Cell Stress and Chaperones, 2020 - Springer
The COVID-19 pandemic needs therapies that are presently available and safe. We propose
that subjects with metabolic syndrome, old age, and male gender have the greatest …

Elucidating of oxidative distress in COVID-19 and methods of its prevention

AM Barciszewska - Chemico-Biological Interactions, 2021 - Elsevier
The pandemic of SARS-CoV-2 stimulates significant efforts and approaches to understand
its global spread. Although the recent introduction of the vaccine is a crucial prophylactic …

Mechanisms of action of ozone therapy in emerging viral diseases: immunomodulatory effects and therapeutic advantages with reference to SARS-CoV-2

A Cenci, I Macchia, V La Sorsa, C Sbarigia… - Frontiers in …, 2022 - frontiersin.org
Medical oxygen-ozone (O2-O3) is a successful therapeutic approach accounting on the
assessed beneficial action of ozone in the range 30–45 μg/ml (expanded range 10–80 …