COVID-19 cytokine storm: the interplay between inflammation and coagulation

RJ Jose, A Manuel - The Lancet Respiratory Medicine, 2020 - thelancet.com
Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the globe. It is
associated with significant mortality, particularly in at-risk groups with poor prognostic …

The versatile heparin in COVID‐19

J Thachil - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
Coagulopathy in coronavirus infection has been shown to be associated with high mortality
with high D-dimers being a particularly important marker for the coagulopathy. 1 In the latest …

Studying the coagulopathy of COVID-19

AC Spyropoulos, MP Bonaca - The Lancet, 2022 - thelancet.com
The coagulopathy caused by SARS-CoV-2 seen in patients hospitalised with COVID-19,
especially those with severe or critical illness, is by now well established. Early reports in …

[HTML][HTML] Pathophysiology of COVID-19-associated acute respiratory distress syndrome

L Camporota, D Chiumello, M Busana… - The Lancet …, 2021 - thelancet.com
We congratulate Giacomo Grasselli and colleagues for their important and informative work
on the pathophysiology of COVID-19-associated acute respiratory distress syndrome …

COVID-19: coagulopathy, risk of thrombosis, and the rationale for anticoagulation

W Miesbach, M Makris - Clinical and applied thrombosis …, 2020 - journals.sagepub.com
The novel coronavirus infection (COVID-19) is caused by the new coronavirus SARS-CoV-2
and is characterized by an exaggerated inflammatory response that can lead to severe …

Endothelial cells orchestrate COVID-19 coagulopathy

JM O'Sullivan, D Mc Gonagle, SE Ward… - The Lancet …, 2020 - thelancet.com
Recent data have shown that coagulation activation is common in patients with severe
COVID-19. 1, 2 Moreover, autopsy studies have reported widespread microthrombi …

Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia

D McGonagle, JS O'Donnell, K Sharif… - The Lancet …, 2020 - thelancet.com
The lung pathology seen in patients with coronavirus disease 2019 (COVID-19) shows
marked microvascular thrombosis and haemorrhage linked to extensive alveolar and …

Assessing the importance of interleukin-6 in COVID-19

LYC Chen, RL Hoiland, S Stukas… - The Lancet …, 2021 - thelancet.com
The systematic review and metaanalysis of interleukin (IL)-6 in COVID-19, by Daniel
Leisman and colleagues, 1 provides a crucial comparison with other inflammatory …

Non-invasive respiratory support strategies in COVID-19

E Gorman, B Connolly, K Couper… - The Lancet …, 2021 - thelancet.com
April 16, 2021 https://doi. org/10.1016/S2213-2600 (21) 00168-5 scaffold for intravascular
thrombus formation. It might also cause thrombotic microangiopathy in the microvasculature …

Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis

JS O'Donnell, F Peyvandi, I Martin-Loeches - Intensive care medicine, 2021 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for
coronavirus disease 2019 (COVID-19). Recent data highlight a pivotal role for pulmonary …