The role of NK cells in rheumatoid arthritis

A Fathollahi, LN Samimi, M Akhlaghi, A Jamshidi… - Inflammation …, 2021 - Springer
Objective Natural killer (NK) cells are part of the innate immune system which not only
provides a primary response to pathogenic conditions but can also play an important …

Natural killer cells and their role in rheumatoid arthritis: friend or foe?

H Shegarfi, F Naddafi… - The Scientific World …, 2012 - Wiley Online Library
Rheumatoid arthritis (RA) is a long‐term disease that leads to inflammation of the joints and
surrounding tissues. Natural killer (NK) cells are an important part of the innate immune …

Natural killer cells infiltration in the joints exacerbates collagen-induced arthritis

L Wu, R Wang, Y Zhou, D Zhao, F Chen, X Wu… - Frontiers in …, 2022 - frontiersin.org
Introduction The role of natural killer (NK) cells in rheumatoid arthritis remains controversial.
We aimed to assess the role of NK cells in the pathogenesis of rheumatoid arthritis …

The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: major contributors or essential homeostatic modulators?

DJ Ahern, FM Brennan - Immunology letters, 2011 - Elsevier
Natural Killer (NK) cells are lymphocytes of the innate immune system, originally described
by their capacity to control tumour cells and eliminate virus-infected cells. However …

Emerging role for NK cells in the pathogenesis of inflammatory arthropathies

P Conigliaro, R Scrivo, G Valesini, R Perricone - Autoimmunity reviews, 2011 - Elsevier
Natural killer (NK) cells are large, granular lymphocytes devoted to the defense against
microbial agents and cancer cells, traditionally recognized as an important arm of the innate …

Natural killer cells in human autoimmune disorders

LA Fogel, WM Yokoyama, AR French - Arthritis research & therapy, 2013 - Springer
Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense
against viruses. Through their cytolytic capacity and generation of cytokines and …

Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype

C Pridgeon, GP Lennon, L Pazmany… - …, 2003 - academic.oup.com
Background. Natural killer (NK) cells play an important role in several animal models of
autoimmunity by modulating T‐cell responses, but it is unclear whether human NK cells …

Altered natural killer cell subsets in seropositive arthralgia and early rheumatoid arthritis are associated with autoantibody status

P Chalan, J Bijzet, BJ Kroesen, AMH Boots… - The Journal of …, 2016 - jrheum.org
Objective. The role of natural killer (NK) cells in the immunopathogenesis of rheumatoid
arthritis (RA) is unclear. Therefore, numerical and functional alterations of CD56dim and …

High percentages and activity of synovial fluid NK cells present in patients with advanced stage active Rheumatoid Arthritis

R Yamin, O Berhani, H Peleg, S Aamar, N Stein… - Scientific reports, 2019 - nature.com
Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and
IFNγ are central players in RA, however their source has not been fully elucidated. Natural …

Phenotypic and functional characterization of natural killer cells in rheumatoid arthritis-regulation with interleukin-15

SJ Lin, CY Hsu, ML Kuo, PT Lee, HS Hsiao… - Scientific Reports, 2020 - nature.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation
and joint destruction. Previous studies have shown that natural killer (NK) cells may play an …