Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to
the yeast Candida albicans in immunocompromised individuals poses a seriously …

Today's research is focused on developing new safe drugs of clinical importance. Nitrogen-
containing heterocycles are abundant in the common of therapeutic scaffolds. Triazoles are …

Triazoles have demonstrated significant efficacy in the treatment of fungal infections.
However, increasing drug resistance is a growing concern that negatively impacts their …

The development of innovative antifungal agents is essential. Some fungicidal agents are no
longer effective due to resistance development, various side effects, and high toxicity …

Candida infections are most prominent among fungal infections majorly target
immunocompromised and hospitalized patients and cause significant morbidity and …

Several five membered ring systems, eg, triazole, oxadiazole dithiazole and thiadiazole with
three heteroatoms at symmetrical or asymmetrical positions have been studied because of …

Heterocyclic compounds, in particular the compounds with 1, 2, 4-triazole core has attracted
a continuously growing interest of synthetic organic chemists and those dealing with the …

In our continuing efforts to discover novel triazoles with improved antifungal activity in vitro
and in vivo, a series of 41 novel compounds containing 1, 2, 3-triazole side chains were …

The risk of opportunistic infections is greatly increased in patients who are
immunocompromised due to AIDS, cancer chemotherapy and organ or bone marrow …

A pharmacophore system has been found as 1, 2, 3‐triazole, a five‐membered heterocycle
ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using …