Partitioning of dispersed nanoparticles in a realistic nasal passage for targeted drug delivery
The complex nasal structure poses obstacles for efficient nasal drug administration beyond
the nasal valve, especially when targeting the olfactory region. This study numerically …
the nasal valve, especially when targeting the olfactory region. This study numerically …
Numerical simulation of airflow, particle deposition and drug delivery in a representative human nasal airway model
H Shi - 2007 - repository.lib.ncsu.edu
The human nasal cavities, each with an effective length of only 10cm, feature a wide array of
basic flow phenomena due to their complex geometries. Dependent on such airflow fields …
basic flow phenomena due to their complex geometries. Dependent on such airflow fields …
Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model
JD Schroeter, JS Kimbell… - Journal of Aerosol …, 2006 - liebertpub.com
The human nasal passages effectively filter particles from inhaled air. This prevents harmful
pollutants from reaching susceptible pulmonary airways, but may leave the nasal mucosa …
pollutants from reaching susceptible pulmonary airways, but may leave the nasal mucosa …
Olfactory targeting of microparticles through inhalation and bi-directional airflow: effect of particle size and nasal anatomy
Background: Targeting drugs to the olfactory region in the nasal cavity can bypass the
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …
Numerical comparison of nasal aerosol administration systems for efficient nose-to-brain drug delivery
Purpose Nose-to-brain drug administration along the olfactory and trigeminal nerve
pathways offers an alternative route for the treatment of central nervous system (CNS) …
pathways offers an alternative route for the treatment of central nervous system (CNS) …
Advanced particulate carrier-mediated technologies for nasal drug delivery
VP Chavda, G Jogi, N Shah, MN Athalye… - Journal of Drug Delivery …, 2022 - Elsevier
Nasal drug delivery has been employed as an alternate and convenient route for the
systemic availability of pharmaceuticals, particularly for potent therapeutics. This is owing to …
systemic availability of pharmaceuticals, particularly for potent therapeutics. This is owing to …
Numerical analysis of nanoparticle transport and deposition in a cynomolgus monkey nasal passage
Environmental exposure to toxic agents is commonly encountered by occupational and
residential populations. However, in vivo exposure data in human subjects is limited by …
residential populations. However, in vivo exposure data in human subjects is limited by …
First steps to develop and validate a CFPD model in order to support the design of nose-to-brain delivered biopharmaceuticals
L Engelhardt, M Röhm, C Mavoungou… - Pharmaceutical …, 2016 - Springer
Purpose Aerosol particle deposition in the human nasal cavity is of high interest in particular
for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The …
for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The …
Numerical and machine learning analysis of the parameters affecting the regionally delivered nasal dose of nano-and micro-sized aerosolized drugs
The nasal epithelium is an important target for drug delivery to the nose and secondary
organs such as the brain via the olfactory bulb. For both topical and brain delivery, the …
organs such as the brain via the olfactory bulb. For both topical and brain delivery, the …
Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity
In this study, the effects of nasal drug delivery device and the spray nozzle orientation on
sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior …
sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior …