Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention

S Lemeer, AM Gholami, Z Wu, B Kuster - Proteomics, 2015 - Wiley Online Library
Uterine leiomyomas are benign tumors affecting a large proportion of the female population.
Despite the very high prevalence, the molecular basis for understanding the onset and …

A proteomic analysis of human uterine myoma

A Rizzello, J Franck, M Pellegrino… - Current Protein and …, 2017 - ingentaconnect.com
Uterine leiomyoma is a benign smooth muscle tumor characterized by a high incidence in
women of reproductive age. The aetiology of this tumor is still unknown but established risk …

Interactome analysis of the differentially expressed proteins in uterine leiomyoma

T Sahar, A Nigam, S Anjum, F Waziri… - Anti-Cancer Agents …, 2019 - ingentaconnect.com
Background: Recent advances in proteomics present enormous opportunities to discover
proteome related disparities and thus understanding the molecular mechanisms related to a …

Secretome profiling and computational biology of human leiomyoma samples unravel molecular signatures with potential for diagnostic and therapeutic interventions

T Sahar, A Nigam, S Anjum, N Gupta, S Wajid - Reproductive Sciences, 2021 - Springer
In recent years, significant advancements have been made in the way the complex
proteome samples are compared but the ultimate goal of routine biomarker discovery has …

Phosphoproteins Involved in the Inhibition of Apoptosis and in Cell Survival in the Leiomyoma

B Ura, L Monasta, G Arrigoni, I Battisti… - Journal of Clinical …, 2019 - mdpi.com
Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium.
In this study we focus on leiomyoma and normal myometrium phosphoproteome, to identify …

Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches

NN Sahly, B Banaganapalli, AN Sahly… - Systems Biology in …, 2021 - Taylor & Francis
Uterine smooth muscular neoplastic growths like benign leiomyomas (UL) and metastatic
leiomyosarcomas (ULMS) share similar clinical symptoms, radiological and histological …

Proteomic identification of plasma biomarkers in uterine leiomyoma

CP Lin, YW Chen, WH Liu, HC Chou, YP Chang… - Molecular …, 2012 - pubs.rsc.org
Recent progresses in quantitative proteomics have offered opportunities to discover plasma
proteins as biomarkers for tracking the progression and for understanding the molecular …

Targeted cellular process profiling approach for uterine leiomyoma using cDNA microarray, proteomics and gene ontology analysis

WS Ahn, KW Kim, SM Bae, JH Yoon… - International journal …, 2003 - Wiley Online Library
This study utilized both cDNA microarray and two‐dimensional protein gel electrophoresis
technology to investigate the multiple interactions of genes and proteins involved in uterine …

O-188 Decoding uterine leiomyoma tumorigenesis using single-cell transcriptomics and single-cell proteomics

A Machado-Lopez, R Pérez-Moraga… - Human …, 2023 - academic.oup.com
Study question Can single-cell transcriptomics and proteomics contribute to a better
understanding uterine of leiomyoma tumorigenesis? Summary answer We demonstrate the …

A proteomic approach for the identification of up-regulated proteins involved in the metabolic process of the leiomyoma

B Ura, F Scrimin, G Arrigoni, C Franchin… - International Journal of …, 2016 - mdpi.com
Uterine leiomyoma is the most common benign smooth muscle cell tumor of the uterus.
Proteomics is a powerful tool for the analysis of complex mixtures of proteins. In our study …