[PDF][PDF] Association analysis of European-derived type 2 diabetes SNPs from whole genome association studies in African Americans

JP Lewis, ND Palmer, PJ Hicks, MM Sale… - Diabetes, 2008 - Citeseer
Objective: Several whole genome association (WGA) studies have reported identification of
type 2 diabetes mellitus (T2DM) susceptibility genes in various European-derived …

Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores

K Läll, R Mägi, A Morris, A Metspalu, K Fischer - Genetics in Medicine, 2017 - nature.com
Purpose: Using effect estimates from genome-wide association studies (GWAS), we
identified a genetic risk score (GRS) that has the strongest association with type 2 diabetes …

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

S Ghatan, J van Rooij, M van Hoek, CG Boer, JF Felix… - Genome Medicine, 2024 - Springer
Abstract Background Type 2 diabetes (T2D) is a heterogeneous and polygenic disease.
Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants …

Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans

J Long, T Edwards, LB Signorello, Q Cai… - American journal of …, 2012 - academic.oup.com
Abstract Type 2 diabetes (T2D) is up to twice as prevalent among African Americans as
Caucasians. Recent genome-wide association studies (GWAS) have identified multiple …

Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population

M Brīvība, I Atava, R Pečulis, I Elbere, L Ansone… - International Journal of …, 2024 - mdpi.com
Numerous type 2 diabetes (T2D) polygenic risk scores (PGSs) have been developed to
predict individuals' predisposition to the disease. An independent assessment and …

Genetics of type 2 diabetes in US Hispanic/Latino individuals: results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Q Qi, AM Stilp, T Sofer, JY Moon, B Hidalgo… - Diabetes, 2017 - Am Diabetes Assoc
Few genome-wide association studies (GWAS) of type 2 diabetes (T2D) have been
conducted in US Hispanics/Latinos of diverse backgrounds who are disproportionately …

[HTML][HTML] Integrated genomic and BMI analysis for type 2 diabetes risk assessment

D Lebrón-Aldea, EJ Dhurandhar… - Frontiers in …, 2015 - frontiersin.org
Type 2 Diabetes (T2D) is a chronic disease arising from the development of insulin absence
or resistance within the body, and a complex interplay of environmental and genetic factors …

A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q

MM Sale, BI Freedman, CD Langefeld, AH Williams… - Diabetes, 2004 - Am Diabetes Assoc
African Americans are at increased risk of type 2 diabetes and many diabetes complications.
We have carried out a genome-wide scan for African American type 2 diabetes using 638 …

Genomic risk score provides predictive performance for type 2 diabetes in the UK biobank

X Chen, C Liu, S Si, Y Li, W Li, T Yuan, F Xue - Acta Diabetologica, 2021 - Springer
Abstract Aims Type 2 diabetes (T2D) is affected by a combination of genetic and
environmental factors. However, the comprehensive genomic risk scores (GRSs) for T2D …

Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies

JP Lewis, ND Palmer, PJ Hicks, MM Sale… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Several whole-genome association studies have reported identification of
type 2 diabetes susceptibility genes in various European-derived study populations. Little …