Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention …
MF Hivert, KA Jablonski, L Perreault, R Saxena… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Over 30 loci have been associated with risk of type 2 diabetes at genome-wide
statistical significance. Genetic risk scores (GRSs) developed from these loci predict …
statistical significance. Genetic risk scores (GRSs) developed from these loci predict …
Validation of type 2 diabetes risk variants identified by genome-wide association studies in Han Chinese population: a replication study and meta-analysis
YC Chang, PH Liu, YH Yu, SS Kuo, TJ Chang… - PloS one, 2014 - journals.plos.org
Background Several genome-wide association studies (GWAS) involving European
populations have successfully identified risk genetic variants associated with type 2 diabetes …
populations have successfully identified risk genetic variants associated with type 2 diabetes …
[PDF][PDF] Type 1 Diabetes Genetic Risk in 109,954 Veterans With Adult-Onset Diabetes: The Million Veteran Program (MVP)
PK Yang, SL Jackson, BR Charest, YJ Cheng… - Diabetes …, 2024 - Am Diabetes Assoc
OBJECTIVE To characterize high type 1 diabetes (T1D) genetic risk in a population where
type 2 diabetes (T2D) predominates. RESEARCH DESIGN AND METHODS Characteristics …
type 2 diabetes (T2D) predominates. RESEARCH DESIGN AND METHODS Characteristics …
Genome-wide interaction with selected type 2 diabetes loci reveals novel loci for type 2 diabetes in African Americans
JM Keaton, JN Hellwege, MCY Ng… - PACIFIC …, 2017 - World Scientific
Type 2 diabetes (T2D) is the result of metabolic defects in insulin secretion and insulin
sensitivity, yet most T2D loci identified to date influence insulin secretion. We hypothesized …
sensitivity, yet most T2D loci identified to date influence insulin secretion. We hypothesized …
[HTML][HTML] Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
N Genet - Nat Genet, 2014 - ncbi.nlm.nih.gov
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …
aggregated published meta-analyses of genome-wide association studies (GWAS) …
The relationship of family history and risk of type 2 diabetes differs by ancestry
BG Kral, DM Becker, LR Yanek, D Vaidya… - Diabetes & …, 2019 - Elsevier
Abstract Aim Type 2 diabetes (T2DM) in a first-degree relative is a risk factor for incident
diabetes. Americans of African ancestry (AA) have higher rates of T2DM than Americans of …
diabetes. Americans of African ancestry (AA) have higher rates of T2DM than Americans of …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
A Mahajan, CN Spracklen, W Zhang, MCY Ng… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study
Background Genome-wide association studies (GWAS) have identified genetic factors in
type 2 diabetes (T2D), mostly among individuals of European ancestry. We tested whether …
type 2 diabetes (T2D), mostly among individuals of European ancestry. We tested whether …
A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research
SM Willems, R Mihaescu, EJG Sijbrands… - Current diabetes …, 2011 - Springer
Fueled by the successes of genome-wide association studies, numerous studies have
investigated the predictive ability of genetic risk models in type 2 diabetes. In this paper, we …
investigated the predictive ability of genetic risk models in type 2 diabetes. In this paper, we …
Use of net reclassification improvement (NRI) method confirms the utility of combined genetic risk score to predict type 2 diabetes
CHT Tam, JSK Ho, Y Wang, VKL Lam, HM Lee… - PloS one, 2013 - journals.plos.org
Background Recent genome-wide association studies (GWAS) identified more than 70
novel loci for type 2 diabetes (T2D), some of which have been widely replicated in Asian …
novel loci for type 2 diabetes (T2D), some of which have been widely replicated in Asian …