[HTML][HTML] Genetic risk profiling for prediction of type 2 diabetes

R Mihaescu, J Meigs, E Sijbrands, AC Janssens - PLoS Currents, 2011 - ncbi.nlm.nih.gov
Abstract Type 2 diabetes (T2D) is a common disease caused by a complex interplay
between many genetic and environmental factors. Candidate gene studies and recent …

A multi-ancestry genome-wide association study in type 1 diabetes

DA Michalek, C Tern, W Zhou… - Human Molecular …, 2024 - academic.oup.com
Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of the
pancreatic β-cells. Genome-wide association (GWAS) and fine mapping studies have been …

Polygenic risk scores predict diabetic complications and their response to therapy

J Tremblay, M Haloui, F Harvey, R Tahir… - MedRxiv, 2019 - medrxiv.org
Type 2 diabetes increases the risk of cardiovascular and renal complications, but early risk
prediction can lead to timely intervention and better outcomes. Through summary statistics of …

Genome-Wide Association studies (GWAS) deliver big breakthroughs in identifying type 2 diabetes susceptibility genes in the general population

W Cui, C Zhang, Y Song - North American Journal of Medicine and …, 2009 - najms.com
A striking epidemic of type 2 diabetes mellitus (T2D) is a major public health problem
worldwide. Current medical therapies can mitigate this disorder, but rarely provide a cure …

Utility of genetic risk scores in type 1 diabetes

AM Luckett, MN Weedon, G Hawkes, RD Leslie… - Diabetologia, 2023 - Springer
Iterative advances in understanding of the genetics of type 1 diabetes have identified> 70
genetic regions associated with risk of the disease, including strong associations across the …

Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

M Van Hoek, A Dehghan, JCM Witteman… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Prediction of type 2 diabetes based on genetic testing might improve
identification of high-risk subjects. Genome-wide association (GWA) studies identified …

Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (project SuGAR)

MM Sale, L Lu, IJ Spruill, JK Fernandes, KH Lok… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—The Gullah-speaking African American population from the Sea Islands of
South Carolina is characterized by a low degree of European admixture and high rates of …

Genetics of type 2 diabetes in African Americans

MCY Ng - Current diabetes reports, 2015 - Springer
Abstract Type 2 diabetes (T2D) is a global health problem showing substantial ethnic
disparity in disease prevalence. African Americans have one of the highest prevalence of …

Diverse type 2 diabetes genetic risk factors functionally converge in a phenotype-focused gene network

C Sandor, NL Beer, C Webber - PLoS computational biology, 2017 - journals.plos.org
Type 2 Diabetes (T2D) constitutes a global health burden. Efforts to uncover predisposing
genetic variation have been considerable, yet detailed knowledge of the underlying …

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …