BACKGROUND Aberrantly methylated genes represent important markers for cancer
diagnosis. We describe a multiplex detection approach to efficiently quantify these markers …

Colorectal carcinoma (CRC) is a common cause of morbidity and mortality worldwide. Two
pathogenic pathways are involved in the development of adenoma to CRC. The first …

Simple Summary Upper gastrointestinal cancer is a major cancer type in China with low 5-
year survival rates due to without cost-effective non-invasive early detection tool. In this …

OBJECTIVES: We recently identified a six-gene methylation-based biomarker panel suitable
for early detection of colorectal cancer (CRC). In this study, we compared the performance of …

Background Multiple epigenetic and genetic changes have been reported in colorectal
tumors, but few of these have clinical impact. This study aims to pinpoint epigenetic markers …

OBJECTIVES While promoter hypermethylation is a common molecular alteration of human
colorectal cancer that could be detected in the bloodstream, we tested the feasibility of …

Background Many methylation markers associated with colorectal cancer have been
reported, but few of them are actually used in clinical practice. Aims This study was designed …

Aberrant DNA methylation occurs early in oncogenesis, is stable, and can be assayed in
tissues and body fluids. Therefore, genes with aberrant methylation can provide clues for …

Objective: Detection of aberrant methylated genes in feces has been developed as an early
screening method for colorectal cancer. The aim of this study was to probe the methylation …

Background Previous studies showed that the assessment of promoter hypermethylation of
a limited number of genes in tumor biopsies may identify the majority of colorectal tumors …