The ongoing SARS-CoV-2 pandemic demonstrates the utility of real-time sequence analysis
in monitoring and surveillance of pathogens. However, cost-effective sequencing requires …

Abstract Background The MinION™ nanopore sequencer was recently released to a
community of alpha-testers for evaluation using a variety of sequencing applications. Recent …

Background Long-read nanopore sequencing technology is of particular significance for
taxonomic identification at or below the species level. For many environmental samples, the …

DNA sequencing and hence genomics have been transformed over the last decade by the
commercialization of inexpensive, massively parallel, short-read sequencing technology …

Realizing the democratic promise of nanopore sequencing requires the development of new
bioinformatics approaches to deal with its specific error characteristics. Here we present …

Abstract Coronavirus disease 2019 (COVID-19) pandemic has been a catastrophic burden
to global healthcare systems. The fast spread of the etiologic agent, severe acute respiratory …

Background Long-read sequencing can be applied to generate very long contigs and even
completely assembled genomes at relatively low cost and with minimal sample preparation …

DNA sequencing was dominated by Sanger's chain termination method until the mid-2000s,
when it was progressively supplanted by new sequencing technologies that can generate …

DNA evidence has long been considered the gold standard for human identification in
forensic investigations. Forensic genetic analyses may harness the information within …

Emerging and re-emerging viruses are a global health concern. Genome sequencing as an
approach for monitoring circulating viruses is currently hampered by complex and expensive …