The NLR pyrin domain containing 3 (NLRP3) inflammasome is a major component of the
innate immune system, but its mechanism of activation by a wide range of molecules …

The inflammasome is a molecular platform formed by activation of an innate immune pattern
recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC …

Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2
infection. In multivariate analysis, advanced age was an independent risk factor for death …

Background Compared to healthy controls, severe COVID19 patients display increased
levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 …

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

Nod-like receptor protein 3 (NLRP3), a therapeutic target that has a close relationship with
inflammatory diseases, has drawn significant attention from researchers in the field. An …

The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …

NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is
activated by pathogen and damage-associated signals to form a multimeric protein complex …

The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …