Immune-mediated cytokine storm and its role in severe dengue

A Srikiatkhachorn, A Mathew, AL Rothman - Seminars in …, 2017 - Springer
Dengue remains one of the most important mosquito-borne diseases worldwide. Infection
with one of the serologically related dengue viruses (DENVs) can lead to a wide range of …

Dysfunctional innate immune responses and severe dengue

GN Malavige, C Jeewandara, GS Ogg - Frontiers in cellular and …, 2020 - frontiersin.org
Although infection with the dengue virus (DENV) causes severe dengue, it causes a mild
self-limiting illness in the majority of individuals. There is emerging evidence that an …

[HTML][HTML] Inflammatory and innate immune responses in dengue infection: protection versus disease induction

VV Costa, CT Fagundes, DG Souza… - The American journal of …, 2013 - Elsevier
Dengue disease is a mosquito-borne viral disease of expanding geographical range and
incidence. Infection by one of the four serotypes of dengue virus induces a spectrum of …

Immune-mediated pathogenesis in dengue virus infection

A Khanam, H Gutiérrez-Barbosa, KE Lyke, JV Chua - Viruses, 2022 - mdpi.com
Dengue virus (DENV) infection is one of the major public health concerns around the globe,
especially in the tropical regions of the world that contribute to 75% percent of dengue …

Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever

J Fink, F Gu, SG Vasudevan - Reviews in medical virology, 2006 - Wiley Online Library
Dengue infections are a major cause of morbidity and mortality in the tropical and sub‐
tropical regions of the world. There is no vaccine for dengue and also there are no anti‐viral …

[HTML][HTML] Cytokine expression in dengue fever and dengue hemorrhagic fever patients with bleeding and severe hepatitis

HA Imad, W Phumratanaprapin, B Phonrat… - The American journal …, 2020 - ncbi.nlm.nih.gov
Dengue is the most common mosquito-borne flaviviral infection in the world today. Several
factors contribute and act synergistically to cause severe infection. One of these is …

A complex interplay among virus, dendritic cells, T cells, and cytokines in dengue virus infections

W Dejnirattisai, T Duangchinda, CLS Lin… - The Journal of …, 2008 - journals.aai.org
Severe dengue virus (DV) infections can cause the life-threatening condition dengue
hemorrhagic fever, which is characterized by a severe plasma leak, thrombocytopenia …

High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection

T Dong, E Moran, N Vinh Chau, C Simmons, K Luhn… - PloS one, 2007 - journals.plos.org
Background Dengue is one of the most important human diseases transmitted by an
arthropod vector and the incidence of dengue virus infection has been increasing–over half …

Highlights for dengue immunopathogenesis: antibody-dependent enhancement, cytokine storm, and beyond

D Kuczera, JP Assolini… - Journal of Interferon & …, 2018 - liebertpub.com
Infection with dengue virus (DENV) can lead to a wide spectrum of clinical presentations,
ranging from asymptomatic infection to death. It is estimated that the disease manifests only …

Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis

UC Chaturvedi, R Agarwal… - FEMS Immunology & …, 2000 - academic.oup.com
Dengue virus produces a mild acute febrile illness, dengue fever (DF) and a severe illness,
dengue hemorrhagic fever (DHF). The characteristic feature of DHF is increased capillary …