Topography-assisted electromagnetic platform for blood-to-PCR in a droplet

CH Chiou, DJ Shin, Y Zhang, TH Wang - Biosensors and Bioelectronics, 2013 - Elsevier
This paper presents an electromagnetically actuated platform for automated sample
preparation and detection of nucleic acids. The proposed platform integrates nucleic acid …

Manipulation and extraction of genomic DNA from cell lysate by functionalized magnetic particles for lab on a chip applications

SW Yeung, IM Hsing - Biosensors and Bioelectronics, 2006 - Elsevier
A novel approach for extracting living cells' genomic DNA materials utilizing functionalized
magnetic particles (MPs) is reported in this investigation. This strategy is amenable to …

On-chip polymerase chain reaction microdevice employing a magnetic droplet-manipulation system

H Tsuchiya, M Okochi, N Nagao, M Shikida… - Sensors and Actuators B …, 2008 - Elsevier
An on-chip polymerase chain reaction (PCR) device employing a magnetic beads-droplet-
handling system was developed. Actuation with a magnet offers a simple system for droplet …

Rapid, multistep on-chip DNA hybridisation in continuous flow on magnetic particles

M Vojtíšek, A Iles, N Pamme - Biosensors and Bioelectronics, 2010 - Elsevier
DNA hybridisation is an important tool for bioanalytical research and clinical diagnostics;
conventional methods, however, require long incubation times and numerous washing …

Magnetic droplet manipulation platforms for nucleic acid detection at the point of care

DJ Shin, TH Wang - Annals of biomedical engineering, 2014 - Springer
This review summarizes recent developments in the use of magnetically actuated droplets in
point-of-care molecular diagnostic platforms. We discuss the fundamentals of magnetic …

Extraction of genomic DNA and detection of single nucleotide polymorphism genotyping utilizing an integrated magnetic bead-based microfluidic platform

KY Lien, CJ Liu, YC Lin, PL Kuo, GB Lee - Microfluidics and Nanofluidics, 2009 - Springer
This study presents a new magnetic bead-based microfluidic platform, which integrates
three major modules for rapid leukocytes purification, genomic DNA (gDNA) extraction and …

On-chip bioanalysis with magnetic particles

N Pamme - Current opinion in chemical biology, 2012 - Elsevier
Magnetic particles can combine two very selective processes in bioanalysis: the specific
binding of analytes to the particle surface based on molecular recognition and the specific …

A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification

Y Zhang, S Park, K Liu, J Tsuan, S Yang, TH Wang - Lab on a Chip, 2011 - pubs.rsc.org
This paper reports a droplet microfluidic, sample-to-answer platform for the detection of
disease biomarkers and infectious pathogens using crude biosamples. The platform …

Magnetic particles for integrated nucleic acid purification, amplification and detection without pipetting

Y Chen, Y Liu, Y Shi, J Ping, J Wu, H Chen - TrAC Trends in Analytical …, 2020 - Elsevier
Nucleic acid amplification based detection plays an important role in food safety,
environmental monitoring and clinical diagnosis. However, traditional nucleic acid detection …

Continuous microfluidic DNA extraction using phase-transfer magnetophoresis

M Karle, J Miwa, G Czilwik, V Auwärter, G Roth… - Lab on a Chip, 2010 - pubs.rsc.org
This paper reports a novel microfluidic-chip based platform using “phase-transfer
magnetophoresis” enabling continuous biomolecule processing. As an example we …