Natural killer cells as indispensable players and therapeutic targets in autoimmunity

FD Shi, Q Zhou - Autoimmunity, 2011 - Taylor & Francis
Natural killer (NK) cells of the innate immune system are equipped with a cytolytic machinery
and produce cytokines, which enable these cells to profoundly modify adaptive immune …

NK cells: elusive players in autoimmunity

S Johansson, L Berg, H Hall, P Höglund - Trends in immunology, 2005 - cell.com
Natural killer (NK) cells were once regarded as relatively simple cells of the innate immune
system. However, they are now revealing themselves as multifunctional regulatory cells that …

Natural killer cells in inflammatory autoimmune diseases

Y Yang, J Day… - Clinical & …, 2021 - Wiley Online Library
Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help
control local immune responses. Through natural cytotoxicity, production of cytokines and …

Natural killer cells: versatile roles in autoimmune and infectious diseases

E Aktas, G Erten, UC Kucuksezer… - Expert review of clinical …, 2009 - Taylor & Francis
Natural killer (NK) cells are essential members of innate immunity and they rapidly respond
to a variety of insults via cytokine secretion and cytolytic activity. Effector functions of NK cells …

The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Natural killer cells in human autoimmunity

M Flodström-Tullberg, YT Bryceson, FD Shi… - Current opinion in …, 2009 - Elsevier
Natural killer (NK) cells are innate immune cells. Although NK cells are best characterized
for their ability to control tumors and infections, recent data have indicated that they also are …

Natural killer cells in inflammation and autoimmunity

B Zitti, YT Bryceson - Cytokine & growth factor reviews, 2018 - Elsevier
First described 40 years ago, natural killer (NK) cells represent the founding members of the
innate lymphoid cell (ILC) family. They were initially defined by their ability to kill cancer cells …

NK cell autoreactivity and autoimmune diseases

A Poggi, MR Zocchi - Frontiers in immunology, 2014 - frontiersin.org
Increasing evidences have pointed out the relevance of natural killer (NK) cells in organ-
specific and systemic autoimmune diseases. NK cells bear a plethora of activating and …

NK cells in autoimmunity: a two-edg'd weapon of the immune system

R Perricone, C Perricone, C De Carolis… - Autoimmunity reviews, 2008 - Elsevier
Natural killer (NK) cells are part of the innate-immune system and respond rapidly to a
variety of insults via cytokine secretion and cytolytic activity. Their main function is first line of …

The natural killer cell–friend or foe in autoimmune disease?

M Flodström, FD Shi, N Sarvetnick… - Scandinavian journal …, 2002 - Wiley Online Library
Autoimmune diseases are chronic conditions resulting from a loss of immunological
tolerance to self‐antigens. Recent observations have supported an ever‐broader role for …