[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

H Liu, NC Wu, M Yuan, S Bangaru, JL Torres… - Immunity, 2020 - cell.com
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …

Symptomatic SARS-CoV-2 infections display specific IgG Fc structures

S Chakraborty, J Gonzalez, K Edwards, V Mallajosyula… - 2020 - pesquisa.bvsalud.org
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
caused a public health crisis that is exacerbated by our poor understanding of correlates of …

Serum Fc-mediated monocyte phagocytosis activity is stable for several months after SARS-CoV-2 asymptomatic and mildly symptomatic infection

S Vangeti, S Periasamy, P Sun, CA Balinsky… - Microbiology …, 2022 - Am Soc Microbiol
We investigated the temporal profile of multiple components of the serological response
after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously …

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

CN Pierre, LE Adams, JS Higgins, K Anasti… - PLOS …, 2024 - journals.plos.org
Antibodies perform both neutralizing and non-neutralizing effector functions that protect
against certain pathogen-induced diseases. A human antibody directed at the SARS-CoV-2 …

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the …

CEZ Chan, SGK Seah, DH Chye, S Massey, M Torres… - PLoS …, 2021 - journals.plos.org
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-
19, little is known about their mechanism (s) of action or effective dosing windows. We report …

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

R Yan, R Wang, B Ju, J Yu, Y Zhang, N Liu, J Wang… - Cell research, 2021 - nature.com
Neutralizing monoclonal antibodies (nAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against …

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

K Vanshylla, C Fan, M Wunsch, N Poopalasingam… - Cell host & …, 2022 - cell.com
A fraction of COVID-19 convalescent individuals mount a potent antibody response to SARS-
CoV-2 with cross-reactivity to SARS-CoV-1. To uncover their humoral response in detail, we …

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Z Lv, YQ Deng, Q Ye, L Cao, CY Sun, C Fan, W Huang… - Science, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health …

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

R Rouet, O Mazigi, GJ Walker, DB Langley, M Sobti… - MAbs, 2021 - Taylor & Francis
Antibodies against coronavirus spike protein potently protect against infection and disease,
but whether such protection can be extended to variant coronaviruses is unclear. This is …