High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
T follicular helper (TFH) cells are the conventional drivers of protective, germinal center (GC)–
based antiviral antibody responses. However, loss of TFH cells and GCs has been observed …
based antiviral antibody responses. However, loss of TFH cells and GCs has been observed …
A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
S Kang, M Yang, S He, Y Wang, X Chen… - Nature …, 2021 - nature.com
Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is …
(SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is …
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody
As the coronavirus disease 2019 (COVID-19) pandemic continues, there is a strong need for
highly potent monoclonal antibodies (mAbs) that are resistant against severe acute …
highly potent monoclonal antibodies (mAbs) that are resistant against severe acute …
Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking
SUMMARY SARS-CoV-2 continues to evolve and evade most existing neutralizing
antibodies, including all clinically authorized antibodies. We have isolated and …
antibodies, including all clinically authorized antibodies. We have isolated and …
[HTML][HTML] BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age
Each severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant renews
concerns about decreased vaccine neutralization weakening efficacy. However, while …
concerns about decreased vaccine neutralization weakening efficacy. However, while …
An anti-SARS-CoV-2 non-neutralizing antibody with Fc-effector function defines a new NTD epitope and delays neuroinvasion and death in K18-hACE2 mice
Emerging evidence in animal models indicate that both neutralizing activity and Fc-mediated
effector functions of neutralizing antibodies contribute to protection against SARS-CoV-2. It …
effector functions of neutralizing antibodies contribute to protection against SARS-CoV-2. It …
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2
Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical
interventions against COVID-19 disease. However, their common genetic and biologic …
interventions against COVID-19 disease. However, their common genetic and biologic …
Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies
Z Ling, C Yi, X Sun, Z Yang, B Sun - Science China Life Sciences, 2023 - Springer
Antibody therapeutics and vaccines for coronavirus disease 2019 (COVID-19) have been
approved in many countries, with most being developed based on the original strain of …
approved in many countries, with most being developed based on the original strain of …
Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages
that are more transmissible and resistant to currently approved antibody therapies poses a …
that are more transmissible and resistant to currently approved antibody therapies poses a …
Multivalency transforms SARS-CoV-2 antibodies into broad and ultrapotent neutralizers
E Rujas, I Kucharska, YZ Tan, S Benlekbir, H Cui… - BioRxiv, 2020 - biorxiv.org
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes
Coronavirus Disease 2019 (COVID-19), has caused a global pandemic. Antibodies are …
Coronavirus Disease 2019 (COVID-19), has caused a global pandemic. Antibodies are …