[HTML][HTML] Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-
mediated immunity. To facilitate prospective surveillance for such evolution, we map how …
mediated immunity. To facilitate prospective surveillance for such evolution, we map how …
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection
H Yao, Y Sun, YQ Deng, N Wang, Y Tan, NN Zhang… - Cell research, 2021 - nature.com
Structural principles underlying the composition and synergistic mechanisms of protective
monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity …
monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity …
Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence
Therapeutic antibodies are an important tool in the arsenal against coronavirus infection.
However, most antibodies developed early in the pandemic have lost most or all efficacy …
However, most antibodies developed early in the pandemic have lost most or all efficacy …
Waning and boosting of antibody Fc-effector functions upon SARS-CoV-2 vaccination
X Tong, RP McNamara, MJ Avendaño… - Nature …, 2023 - nature.com
Since the emergence of SARS-CoV-2, vaccines targeting COVID-19 have been developed
with unprecedented speed and efficiency. CoronaVac, utilising an inactivated form of the …
with unprecedented speed and efficiency. CoronaVac, utilising an inactivated form of the …
Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern
IA Favorskaya, DV Shcheblyakov… - Frontiers in …, 2022 - frontiersin.org
Virus-neutralizing antibodies are one of the few treatment options for COVID-19. The
evolution of SARS-CoV-2 virus has led to the emergence of virus variants with reduced …
evolution of SARS-CoV-2 virus has led to the emergence of virus variants with reduced …
Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective
Y Huang, H Sun, H Yu, S Li, Q Zheng… - Antibody …, 2020 - academic.oup.com
The rapid emergence of Coronavirus disease-2019 (COVID-19) caused by severe acute
respiratory syndrome 2 coronavirus (SARS-CoV-2) as a pandemic that presents an urgent …
respiratory syndrome 2 coronavirus (SARS-CoV-2) as a pandemic that presents an urgent …
Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening
Monoclonal antibodies that target SARS-CoV-2 with high affinity are valuable for a wide
range of biomedical applications involving novel coronavirus disease (COVID-19) …
range of biomedical applications involving novel coronavirus disease (COVID-19) …
Broadly-neutralizing antibodies against emerging SARS-CoV-2 variants
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
have become a major concern in the containment of current pandemic. The variants …
have become a major concern in the containment of current pandemic. The variants …
A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection
Most neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
binding domain (RBD) of the spike (S) protein. Here, we characterize a panel of mAbs …
Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy
Understanding how potent neutralizing antibodies (NAbs) inhibit SARS-CoV-2 is critical for
effective therapeutic development. We previously described BD-368-2, a SARS-CoV-2 NAb …
effective therapeutic development. We previously described BD-368-2, a SARS-CoV-2 NAb …