[HTML][HTML] Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins

Y Li, Z Xu, Q Lei, D Lai, H Hou, H Jiang, Y Zheng… - Cell reports, 2021 - cell.com
The immunogenicity of the SARS-CoV-2 proteome is largely unknown, especially for non-
structural proteins and accessory proteins. In this study, we collect 2,360 COVID-19 sera and …

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

D Fu, G Zhang, Y Wang, Z Zhang, H Hu, S Shen… - PLoS …, 2021 - journals.plos.org
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and …

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

H Sun, T Deng, Y Zhang, Y Lin, Y Jiang, Y Jiang… - Protein & …, 2024 - academic.oup.com
Continual evolution of the severe acute respiratory syndrome coronavirus (SARS-CoV-2)
virus has allowed for its gradual evasion of neutralizing antibodies (nAbs) produced in …

Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern

AA Gorchakov, SV Kulemzin, SV Guselnikov… - Cell Discovery, 2021 - nature.com
In the absence of virus-targeting small-molecule drugs approved for the treatment and
prevention of COVID-19, broadening the repertoire of potent SARS-CoV-2-neutralizing …

Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2

SR Mackin, P Desai, BM Whitener, CE Karl, M Liu… - Nature …, 2023 - nature.com
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with
antigenic changes in the spike protein are neutralized less efficiently by serum antibodies …

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

Structure-based neutralizing mechanisms for SARS-CoV-2 antibodies

Q Huang, X Han, J Yan - Emerging Microbes & Infections, 2022 - Taylor & Francis
The devastating economic and public health consequences caused by the COVID-19
pandemic have prompted outstanding efforts from the scientific community and …

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

A Schäfer, F Muecksch, JCC Lorenzi, SR Leist… - Journal of Experimental …, 2020 - rupress.org
SARS-CoV-2, the causative agent of COVID-19, has been responsible for over 42 million
infections and 1 million deaths since its emergence in December 2019. There are few …

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Z Ku, X Xie, E Davidson, X Ye, H Su… - Nature …, 2021 - nature.com
Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The
determinants for selecting antibody combinations and the mechanism that antibody cocktails …

SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus

M Dogan, L Kozhaya, L Placek, C Gunter… - Communications …, 2021 - nature.com
Abstract Development of antibody protection during SARS-CoV-2 infection is a pressing
question for public health and for vaccine development. We developed highly sensitive …