[HTML][HTML] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

F Muecksch, Y Weisblum, CO Barnes, F Schmidt… - Immunity, 2021 - cell.com
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …

Neutralizing antibodies targeting the SARS‐CoV‐2 receptor binding domain isolated from a naïve human antibody library

BN Bell, AE Powell, C Rodriguez, JR Cochran… - Protein …, 2021 - Wiley Online Library
Infection with SARS‐CoV‐2 elicits robust antibody responses in some patients, with a
majority of the response directed at the receptor binding domain (RBD) of the spike surface …

Broadly neutralizing antibodies to SARS-CoV-2 provide novel insights into the neutralization of variants and other human coronaviruses

P Bajpai, V Singh, A Chandele… - Frontiers in Cellular and …, 2022 - frontiersin.org
Seven coronaviruses are known to cause infection/disease in humans. Of these, human
coronavirus (HCoV)-229E and HCoV-NL63 are alphacoronaviruses (α-CoVs), whereas …

Enhancement versus neutralization by SARS-CoV-2 antibodies from a convalescent donor associates with distinct epitopes on the RBD

Y Zhou, Z Liu, S Li, W Xu, Q Zhang, IT Silva, C Li, Y Wu… - Cell Reports, 2021 - cell.com
Several potent neutralizing antibodies against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) virus have been identified. However, antibody-dependent …

Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

YC Bartsch, X Tong, J Kang, MJ Avendaño… - Science translational …, 2022 - science.org
The Omicron variant of SARS-CoV-2 has been shown to evade neutralizing antibodies
elicited by vaccination or infection. Despite the global spread of the Omicron variant, even …

[HTML][HTML] Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies

J Dufloo, L Grzelak, I Staropoli, Y Madec, L Tondeur… - Cell Reports …, 2021 - cell.com
Summary Many SARS-CoV-2-infected individuals remain asymptomatic. Little is known
about the extent and quality of their antiviral humoral response. Here, we analyze antibody …

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants

X Chi, L Xia, G Zhang, X Chi, B Huang, Y Zhang… - Cell Discovery, 2023 - nature.com
The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread around the world.
Mutant strains of SARS-CoV-2 are constantly emerging. At present, Omicron variants have …

Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies

A Dippel, A Gallegos, V Aleti, A Barnes, X Chen… - Mabs, 2023 - Taylor & Francis
To combat the COVID-19 pandemic, potential therapies have been developed and moved
into clinical trials at an unprecedented pace. Some of the most promising therapies are …

Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants

T Ozawa, H Tani, Y Anraku, S Kita, E Igarashi, Y Saga… - MAbs, 2022 - Taylor & Francis
Many potent neutralizing SARS-CoV-2 antibodies have been developed and used for
therapies. However, the effectiveness of many antibodies has been reduced against recently …

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

P Ren, Y Hu, L Peng, L Yang, K Suzuki… - … and Targeted Therapy, 2023 - nature.com
SARS-CoV-2 rapidly evolves during the pandemic 1 with many variants of concern (VoCs)
lineages (Supplementary Fig. S1a). Omicron (B. 1.1. 529) and its sub-lineages led to …