Combined use of Monte Carlo DNA damage simulations and deterministic repair models to examine putative mechanisms of cell killing

DJ Carlson, RD Stewart, VA Semenenko… - Radiation …, 2008 - meridian.allenpress.com
Abstract Carlson, DJ, Stewart, RD, Semenenko, VA and Sandison, GA Combined Use of
Monte Carlo DNA Damage Simulations and Deterministic Repair Models to Examine …

Spectrum of radiation-induced clustered non-DSB damage–A Monte Carlo track structure modeling and calculations

R Watanabe, S Rahmanian, H Nikjoo - Radiation research, 2015 - meridian.allenpress.com
The aim of this report is to present the spectrum of initial radiation-induced cellular DNA
damage [with particular focus on non-double-strand break (DSB) damage] generated by …

A new standard DNA damage (SDD) data format

J Schuemann, AL McNamara… - Radiation …, 2019 - meridian.allenpress.com
Our understanding of radiation-induced cellular damage has greatly improved over the past
few decades. Despite this progress, there are still many obstacles to fully understand how …

Two-lesion kinetic model of double-strand break rejoining and cell killing

RD Stewart - Radiation research, 2001 - meridian.allenpress.com
Abstract Stewart, RD Two-Lesion Kinetic Model of Double-Strand Break Rejoining and Cell
Killing. Radiat. Res. 156, 365–378 (2001). Radiobiological models, such as the lethal and …

Track structure, lesion development, and cell survival

DJ Brenner - Radiation Research, 1990 - meridian.allenpress.com
A stochastic track-structure-dependent model is presented based on DNA double-strand
breaks (DSBs) interacting in a time-and distance-dependent manner, and in competition …

Monte Carlo simulation of DNA damage induction by x-rays and selected radioisotopes

Y Hsiao, RD Stewart - Physics in Medicine & Biology, 2007 - iopscience.iop.org
To better assess the potential biological consequences of diagnostic x-rays and selected γ-
emitting radioisotopes used in brachytherapy, we used the PENELOPE Monte Carlo …

Equivalence of the linear–quadratic and two-lesion kinetic models

M Guerrero, RD Stewart, JZ Wang… - Physics in Medicine & …, 2002 - iopscience.iop.org
Double strand breaks (DSBs) are widely accepted as the main type of DNA damage
responsible for cell killing in the range of doses and dose rates relevant to radiation therapy …

Monte Carlo simulation of base and nucleotide excision repair of clustered DNA damage sites. II. Comparisons of model predictions to measured data

VA Semenenko, RD Stewart - Radiation research, 2005 - meridian.allenpress.com
Abstract Semenenko, VA and Stewart, RD Monte Carlo Simulation of Base and Nucleotide
Excision Repair of Clustered DNA Damage Sites. II. Comparisons of Model Predictions to …

Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response

TJ Jenner, J Fulford, P O'neill - Radiation research, 2001 - meridian.allenpress.com
Abstract Jenner, TJ, Fulford, J. and O'Neill, P. Contribution of Base Lesions to Radiation-
Induced Clustered DNA Damage: Implication for Models of Radiation Response. Radiat …

Review the link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair

R K. SACHS, P. HAHNFELD and DJ … - International journal of …, 1997 - Taylor & Francis
Purpose: To review current opinion on the production and temporal evolution of low-LET
radiobiological damage. Methods: Standard cell survival models which model …