Oligonucleotides, comprising single or double strands of RNA or DNA, are vital chemical
compounds used in various laboratory and clinical applications. They represent a significant …

The two-day meeting 'Oligonucleotide technologies', organised by IBC Global Conferences
Limited and chaired by M Gait (Medical Research Council, UK), was the first event of this …

Conspectus Chemically modified oligonucleotides are being developed as a new class of
medicines for curing conditions that previously remained untreatable. Three primary classes …

Following the first proof of concept of using small nucleic acids to modulate gene
expression, a long period of maturation led, at the end of the last century, to the first …

In order to offer an exhaustive report on the history of oligonucleotide synthesis, it would be
necessary to examine the history of modern biotechnology, for the two are tightly interwoven …

Progress in the field of oligonucleotide therapeutics has created the need for scale-up of
oligonucleotide synthesis from milligram to multikilogram and higher. The synthesis and …

Over the past several decades, the concept of using molecules composed partially or wholly
of nucleic acids as therapeutic moieties, and the modification of such molecules via synthetic …

Background Oligonucleotide therapeutics have emerged as a promising and dynamic class
of pharmaceutical agents with remarkable potential for treating a wide spectrum of genetic …

Recent studies have focused on the ability of oligonucleotides to affect the genetic
processes of many organisms, including viruses. Hence, oligonucleotides may represent a …

A critical step in the manufacturing of oligonucleotides is the selection of ideal solid
supports. Herein, we evaluate a hybrid core–shell solid support made of polystyrene and …